| clonicity | The state of being clonic. (05 Mar 2000) |
|---|---|
| clonicotonic | Both clonic and tonic; said of certain forms of muscular spasm. (05 Mar 2000) |
| clonidine | <chemical> An alpha-2 adrenergic agonist that crosses the blood-brain barrier. Clonidine's central actions reduce sympathetic tone. It is used as an antihypertensive agent, and has also been used in the treatment of migraine and in the diagnosis of pheochromocytoma. Pharmacological action: adrenergic alpha-agonists, antihypertensive agents, sympatholytics. Chemical name: 1H-Imidazol-2-amine, N-(2,6-dichlorophenyl)-4,5-dihydro- (12 Dec 1998) |
| clonidine hydrochloride | 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride;an antihypertensive agent with central and peripheral actions; it stimulates adrenergic receptors in the brain leading to reduced sympathetic nervous system output. (05 Mar 2000) |
| cloning | <molecular biology> The process whereby clones are established asexually, where cells all genetically identical, to a single ancestor. In recombinant DNA technology, the use of DNA manipulation procedures to produce multiple copies of a single gene or segment of DNA is referred to as cloning DNA. The term covers various manipulations for isolating and establishing clones. In simple systems single cells may be isolated without precise knowledge of their genotype. In other systems partial or complete selection of chosen genotypes can be manipulated with gene cloning. In plants the term refers to natural or artificial vegitative propagation. (12 Mar 1998) |
| cloning vector | <molecular biology> A DNA molecule originating from a virus (plasmid vector), or the cell of a higher organism into which another DNA fragment of appropriate size can be integrated without loss of the vectors capacity for self- replication. Vectors introduce foreign DNA into host cells, where it can be reproduced in large quantities. They are also used to insert DNA from one cell type to another. Examples are plasmids, cosmids, and yeast artificial chromosomes, vectors are often recombinant molecules containing DNA sequences from several sources. Cloning vectors are usually designed to have convenient restriction sites that can be cut to generate sticky end to which the DNA that is to be cloned can be ligated easily. (12 Mar 1998) |
| cloning, cell | The process of producing a group of cells (clones), all genetically identical, from a single ancestor. (12 Dec 1998) |
| cloning, DNA | The use of DNA manipulation procedures to produce multiple copies of a single gene or segment of DNA. (12 Dec 1998) |
| cloning, molecular | The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells. (12 Dec 1998) |
| cloning, organism | The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, foetus-derived, or taken from an adult somatic cell. (12 Dec 1998) |
| clonism | A long continued state of clonic spasms. (05 Mar 2000) |
| clonixin | <chemical> Anti-inflammatory analgesic. Pharmacological action: non-steroidal anti-inflammatory agents. Chemical name: 3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)- (12 Dec 1998) |
| clonogenic | Arising from or consisting of a clone. (05 Mar 2000) |
| clonogenic assay | In vitro culturing of neoplastic cells to test their radiosensitivity or chemosensitivity, and probable clinical efficacy of a therapeutic agent. (05 Mar 2000) |
| clonogenic cell | A cell that has the potential to proliferate and give rise to a colony of cell's; some daughter cell's from each generation retain this potential to proliferate. (05 Mar 2000) |