| excitatory amino acid antagonists | Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (12 Dec 1998) |
|---|---|
| 1-carbamoyl-L-amino acid amidohydrolase | <enzyme> From bacillus stearothermophilus; amino acid sequence given in first source Registry number: EC 3.5.1.- Synonym: carbamoyl l-aa amidohydrolase, n-carbamyl-l-amino acid amidohydrolase (26 Jun 1999) |
| acetate replacement factor | <biochemistry> 1,2 dithiolane 3 valeric acid. Regarded as a coenzyme in the oxoglutarate dehydrogenase complex of the citric acid cycle. Involved generally in oxidative decarboxylations of _ keto acids. A growth factor for some organisms. (18 Nov 1997) |
| arthroplasty, replacement | Partial or total replacement of a joint. (12 Dec 1998) |
| arthroplasty, replacement, hip | Replacement of the hip joint. (12 Dec 1998) |
| arthroplasty, replacement, knee | Replacement of the knee joint. (12 Dec 1998) |
| renal replacement therapy | Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys. (12 Dec 1998) |
| replacement | 1. The act of replacing. 2. <chemistry> The removal of an edge or an angle by one or more planes. Source: Websters Dictionary (01 Mar 1998) |
| replacement bone | A bone that develops in a cartilage environment after the latter is partially or entirely destroyed by calcification and subsequent resorption. Synonym: cartilage bone, replacement bone. (05 Mar 2000) |
| replacement fibrosis | The formation of fibrous tissue that occupies sites where various other cells and tissues have become atrophied, or degenerated and necrotic. (05 Mar 2000) |
| replacement therapy | Therapy designed to compensate for a lack or deficiency arising from inadequate nutrition, from certain dysfunctions (e.g., glandular hyposecretion), or from losses (e.g., haemorrhage); replacement may be physiological or may entail administration of a substitute (e.g., a synthetic oestrogen in place of estradiol). (05 Mar 2000) |
| replacement vector | A cloning vector, such as a bacteriophage, in which some of the DNA of the vector can be replaced with foreign DNA. (09 Oct 1997) |
| hip replacement | Surgery to replace all or part of the hip joint with an artificial device that re-establishes normal hip joint motion. Indicated in cases of severe intractable degenerative arthritis (DJD). (27 Sep 1997) |
| hormone replacement therapy | In females, treatment with sex hormones for a number for reasons, including menopause, partial or full hysterectomy, or amenorrhoea.In women, treatment with sex hormones is indicated for a number of reasons, including menopause, partial or full hysterectomy, or amenorrhoea. After menopause, conjugated oestrogens, estradiol, or estrone sulfate are given to reduce pain during intercourse, limit blood vessel effects, and prevent loss of bone mass. After radical hysterectomy, conjugated oestrogens are given for similar reasons. After menopause or partial hysterectomy, progestin is administered at the same time to offset an increased risk of endometrial cancer. In some amenorrhoeas, oestrogen is given to restore menses; if the therapy is unsuccessful, this may indicate the presence of pathology, for instance, pituitary tumour. Benefits for postmenopausal women include a lowered risk of heart attack (oestrogen lowers LDL and raises HDL levels), and prevention of osteoporosis, since the rate of bone loss is directly linked to a drop in oestrogen levels (see perimenopause). Medical opinion about the hazard posed by such therapy remains divided. Some studies have indicated increased incidence of breast cancer; however, a comprehensive 1992 review of the literature contradicted this finding. (05 Mar 2000) |
| oestrogen replacement therapy | <endocrinology, gynaecology> The use of oestrogenic substances in postmenopausal or other oestrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, dyspareunia, and progressive development of osteoporosis. (12 Dec 1998) |