| PAS | 1) Periodic Acid-Schiff Stain 2) Para-Amino-Salicyclic Acid &nbs... |
|---|---|
| Asx | amino acid that gives aspartic acid after hydrolysis; asymptomatic |
| OA | obstructive apnea; occipital artery; occipito-anterior; occiput anterior; octanoic acid; ocular albi... |
| PAA | partial agonist activity; phenylacetic acid; phosphonoacetic acid; physical abilities analysis; plas... |
| FAF | fatty acid free; fibroblast-activating factor |
| excitatory amino acid | <biochemistry> The naturally occurring amino acids L glutamate and L aspartate and their synthetic analogues, notably kainate, quisqualate and NMDA. They have the properties of excitatory neurotransmitters in the CNS, may be involved in long-term potentiation and can act as excitotoxins. at least three classes of EAA receptor have been identified, the agonists of the N type receptor are L aspartate, NMDA and ibotenate, the agonists of the Q type receptor are L glutamate and quisqualate, agonists of the K type are L glutamate and kainate. All three receptor types are found widely in the CNS and particularly the telencephalon, N and Q type receptors tend to occur together and may interact, their distribution is complementary to the K type receptors. The ion fluxes through the Q and K receptors are relatively brief, whereas the flux through the N type is longer and carries a significant amount of calcium. Additionally the N type receptor is blockaded by magnesium near the resting potential and thus shows voltage gated ion channel properties, leading to a regenerative response, this is why N type receptors have been linked to long-term potentiation. Invertebrate glutamate receptors may not have the same properties as those described above. (18 Nov 1997) |
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| excitatory amino acid agents | Drugs used for their actions on any aspect of excitatory amino acid neurotransmitter systems. Included are drugs that act on excitatory amino acid receptors, affect the life cycle of excitatory amino acid transmitters, or affect the survival of neurons using excitatory amino acids. (12 Dec 1998) |
| excitatory amino acid agonists | Drugs that bind to and activate excitatory amino acid receptors. (12 Dec 1998) |
| excitatory amino acid antagonists | Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (12 Dec 1998) |
| 1-carbamoyl-L-amino acid amidohydrolase | <enzyme> From bacillus stearothermophilus; amino acid sequence given in first source Registry number: EC 3.5.1.- Synonym: carbamoyl l-aa amidohydrolase, n-carbamyl-l-amino acid amidohydrolase (26 Jun 1999) |
| anionic neutrophil activating peptide | <cytokine> A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4. Acronym: IL-8 (12 Dec 1998) |
| p53-activating kinase | <enzyme> Regulates p53 activity in saccharomyces cerevisiae; 810 amino acid residues; genbank u24167; do not confuse with pak I, protease-activated kinase Registry number: EC 2.7.10.- Synonym: pak1 gene product, yeast pak1 (26 Jun 1999) |
| macrophage-activating factor | An agent that stimulates macrophages to attack and ingest cancer cells. They are secreted by stimulated lymphocytes that prime macrophages to become non-specifically cytotoxic to tumours. They also modulate the expression of macrophage cell surface ia antigens. One maf is interferon-gamma (interferon type II). Other factors antigenically distinct from ifn-gamma have also been identified. (12 Dec 1998) |
| virus activating protease | <enzyme> Endoprotease from chick embryo; activates para- and orthomyoxovirus fusion glycoproteins by cleaving them at a single arginine site; ca(2+) dependent; similar to blood clotting factor x Registry number: EC 3.4.21.- (26 Jun 1999) |
| reticular activating system | <physiology> A physiological term denoting that part of the brainstem reticular formation that plays a central role in the organism's bodily and behavorial alertness. It extends as a diffusely organised neural apparatus through the central region of the brainstem into the subthalamus and the intralaminar nuclei of the thalamus; by its ascending connections it affects the function of the cerebral cortex in the sense of behavioural responsiveness; its descending (reticulospinal) connections transmit its activating influence upon bodily posture and reflex mechanisms (e.g., muscle tonus), in part by way of the gamma motor neurons. See: reticular formation. Synonym: non-specific system. (05 Mar 2000) |
| GTPase activating protein | <molecular biology> Originally purified as a 125 kD protein from bovine brain (1044 amino acids), stimulates the GTPase activity of ras p21 and thereby switches it to the inactive state. GAP may itself be regulated by phospholipids and by phosphorylation on a tyrosine residue by growth factor receptors (PDGF R, EGF R). The neurofibromatosis type 1 gene NF1) codes for a protein homologous to GAP. GAP has both SH2 and SH3 domains. Another example is sar 1 (from yeast). (18 Nov 1997) |
| monocyte chemotactic and activating factor | Cytokine of the C C subfamily, co induced with IL-8 on stimulation of endothelial cells, fibroblasts or monocytes that activates and is chemotactic for, monocytes. A chemokine. (18 Nov 1997) |
| complement activating enzymes | <enzyme> Enzymes present in the complement system which activate one or more components in the system. Registry number: EC 3.- (12 Dec 1998) |
| platelet-activating factor | <cytokine> Potent phospholipid activator and mediator of many leucocyte functions, including platelet aggregation, inflammation, and anaphylaxis. It is produced in response to specific stimuli by a variety of cell types, including neutrophils, basophils, platelets, and endothelial cells. Several molecular species of platelet-activating factor have been identified which vary in the length of the O-alkyl side chain. It is an important mediator of bronchoconstriction. Synonym: platelet-aggregating factor. Acronym: PAF (20 Sep 2002) |
| connective tissue activating peptide III | Cytokine, produced from platelet basic protein, that acts as a growth factor. (18 Nov 1997) |