| alpha-acetolactic acid | An intermediate in pyruvic acid catabolism and valine biosynthesis; CH3COC(OH)(CH3)-COOH. (05 Mar 2000) |
|---|---|
| alpha-actinin | An F-actin binding protein in vertebrate cells that cross-links actin filaments into regular parallel arrays. (05 Mar 2000) |
| alpha-adrenergic blocking agent | An agent that competitively blocks alpha-adrenergic receptors; used in the treatment of hypertension. Synonym: alpha-blocker. (05 Mar 2000) |
| alpha-adrenergic receptors | Adrenergic receptor's in effector tissues capable of selective activation and blockade by drugs; conceptually derived from the ability of certain agents, such as phenoxybenzamine, to block only some adrenergic receptor's and of other agents, such as methoxamine, to activate only the same adrenergic receptor's. Such receptor's are designated as alpha-receptors. Their activation results in physiological responses such as increased peripheral vascular resistance, mydriasis, and contraction of pilomotor muscles. (05 Mar 2000) |
| alpha-allocortol | 5alpha-Pregnane-3a,11b,17,20a,21-pentaol;the 5a enantiomer of alpha-cortol; a metabolite of hydroxycortisone found in the urine. (05 Mar 2000) |
| alpha-allocortolone | 3a,17,20a,21-Tetrahydroxy-5alpha-pregnane-11-one;the 5a enantiomer of alpha-cortolone; a metabolite of hydrocortisone found in urine. (05 Mar 2000) |
| alpha-allopregnanediol | 5alpha-Pregnane-3a,20alpha-diol;a metabolite of progesterone and adrenocortical hormones, found in urine. (05 Mar 2000) |
| alpha-amanitin | <drug> A highly toxic, heat-stable bicyclic oligopeptide derived from the Amanita phalloides mushroom. It inhibits transcription by interfering with the function of certain RNA polymerases. (14 Aug 2000) |
| alpha-amino acid | Typically, an amino acid of the general formula R-CHNH2-COOH (i.e., the NH2 in the a position); the l forms of these are the hydrolysis products of proteins. In rarer usages, this class of molecules also includes alpha-amino phosphoric acids and alpha-aminosulfonic acids. (05 Mar 2000) |
| alpha-amino acid esterase | <enzyme> Converts alpha-amino acid esters and water to alpha-amino acids and alcohol Registry number: EC 3.1.1.43 Synonym: alpha-amino acid ester hydrolase (26 Jun 1999) |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | <chemical> Alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid. An ibotenic acid homolog and glutamate agonist. The compound is the defining agonist for the ampa subtype of glutamate receptors (receptors, ampa). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies. Pharmacological action: excitatory amino acid agonists. Chemical name: 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo- (12 Dec 1998) |
| alpha-amino-beta-ketoadipic acid | 2-Amino-3-oxo-1,6-hexanedioic acid;an intermediate of porphobilinogen synthesis formed by d-aminolevulinic acid synthase from succinyl-CoA and glycine; it rapidly decarboxylates to d-aminolevulinic acid. (05 Mar 2000) |
| alpha-aminoacyl-peptide hydrolases | <enzyme> Registry number: EC 3.4.11. (12 Dec 1998) |
| alpha-aminoadipic acid | 2-amino-1,6-hexanedioic acid;an intermediate of lysine biosynthesis in higher fungi and bacteria, but not in algae and higher plants. Also in degradation of lysine in mammals. (05 Mar 2000) |
| alpha-aminoadipyl-cysteinyl-valine synthetase | <enzyme> As of 9/27/95 this has been separated from isopenicillin n synthetase Registry number: EC 6.3.2.- Synonym: acv synthetase, aa-cysteine synthetase, delta-(alpha-aminoadipyl)-cys-val synthetase, delta-(l-alpha-aminoadipyl)-l-cyteinyl-d-valine synthetase, pcbab gene product, acva gene product (26 Jun 1999) |
| Goodenough draw-alpha-man test | A brief test for assessing an individual's level of intelligence based on how accurately drawn and how many elements are included when a child or adult is given a pencil and sheet of white paper and asked to draw a man, the best man he or she is able to draw. Also called the Goodenough draw-alpha-person test and, in its current form, the Goodenough-Harris drawing test. (05 Mar 2000) |
|---|---|
| cholesterol 7 alpha-monooxygenase | <enzyme> An enzyme that catalyses the hydroxylation of cholesterol to cholest-5-en-3 beta,7 alpha-diol. Chemical name: Cholesterol,NADPH:oxygen oxidoreductase (7 alpha-hydroxylating) Registry number: EC 1.14.13.17 (12 Dec 1998) |
| RNase alpha | <enzyme> An enzyme catalyzing endonucleolytic cleavage of O-methylated RNA yielding 5'-phosphomonoesters. (05 Mar 2000) |
| phycocyanin alpha-subunit phycocyanobilin lyase | <enzyme> Cleaves thioether bond attaching phycocyanobilin to the alpha subunit of phycocyanin; product of the cpce and cpcf genes of synechococcus Registry number: EC 4.4.- Synonym: phycocyanobilin lyase (26 Jun 1999) |
| phycoerythrocyanin alpha-subunit phycobiliviolin lyase | <enzyme> Shows high degree of homology to phycocyanobilin lyase Registry number: EC 4.4.- Synonym: phycobiliviolin lyase, pece protein, pecf protein, pec alpha-subunit phycobiliviolin lyase (26 Jun 1999) |
| phytanic acid alpha-oxidase | <enzyme> May be the genetic defect in refsum's disease Registry number: EC 1.14.99.- Synonym: phytanic acid alpha-hydroxylase (26 Jun 1999) |
| p-nitrophenyl-alpha-L-rhamnopyranohydrolase | <enzyme> Active toward naringin, hesperidin and p-nitrophenylrhamnosides; specific for alpha-1,2- or alpha-1,6- linkages to beta-d-glucose Registry number: EC 3.2.1.- Synonym: pnp-rhamnohydrolase (26 Jun 1999) |
| polymerase alpha | A class of mammalian DNA polymerases in the nucleus that function in chromosome replication. Synonym: polymerase a. (05 Mar 2000) |
| pregnancy-associated alpha-plasma protein | An alpha 2-macroglobulin, molecular weight approximately 750,000 now believed to be a pregnancy-specific protein. Its plasma levels increase steadily during the second trimester and continue to rise until the end of gestation. (12 Dec 1998) |
| progesterone 5 alpha-reductase | <enzyme> Do not confuse this with progesterone reductase which is a 3 beta-hydroxysteroid dehydrogenase Registry number: EC 1.3.1.30 (26 Jun 1999) |
| saturated steroid 6 alpha-hydroxylase | <enzyme> Acts on 5 alpha-androstane-3 beta,17 beta-diol and 5 alpha-pregnan-3 beta-ol-20-one; does not require cytochrome p-450 Registry number: EC 1.14.99.- Synonym: sat steroid 6alpha-hydroxylase (26 Jun 1999) |
| pro-transforming growth factor-alpha processing protease | <enzyme> Converts membrane-bound protgf-alpha to soluble tgf-alpha; mw 84 kD Registry number: EC 3.4.21.- Synonym: protgf-alpha converting enzyme, protgfalpha processing protease (26 Jun 1999) |
| Sia(alpha2,3)Gal(beta1,4)GlcNAc alpha-2,8-sialyltransferase | <enzyme> An alpha-2,8-sialyltransferase that exhibits activity toward the sia(alpha2,3)gal(beta1,4)glcnac sequences of n-linked oligosaccharides; involved in brain development; amino acid sequence given in first source Registry number: EC 2.4.99.- Synonym: st8sia III (26 Jun 1999) |
| N-acetyl-alpha-D-galactosaminyloligosaccharidase | <enzyme> From clostridium perfringens; cleaves oligosaccharides larger than disaccharides bound by o-glycosyl linkages to protein Registry number: EC 3.2.1.- Synonym: nag-oligosaccharidase, n-acetylgalactosamine oligosaccharidase (26 Jun 1999) |
| N-acetylated-alpha-linked acidic dipeptidase | <enzyme> Chloride-dependent membrane bound metallopeptidase, most active with the endogenous neuropeptide n-acetyl-l-aspartyl-l-glutamate Registry number: EC 3.4.13.- Synonym: naaladase, glutamate carboxypeptidase II, prostate-specific membrane antigen, psm antigen (26 Jun 1999) |