| mouse leukaemia viruses | Retroviruses of the murine leukaemia-sarcoma complex that produce leukaemia and sometimes lymphosarcomas in mice, including the Abelron, Gross, Moloney, Friend, and Rauscher strains of virus; they have been isolated from inbred mice having high incidence of spontaneous lymphoid leukaemia. (05 Mar 2000) |
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| plasma cell leukaemia | An unusual disease characterised by leukocytosis and other signs and symptoms that are suggestive of leukaemia, in association with diffuse infiltrations and aggregates of plasma cells in the spleen, liver, bone marrow, and lymph nodes, and the presence of considerable numbers of plasma cells in the circulating blood; the total number of leukocytes in the latter may range from normal levels to 80,000 or 90,000 per cu mm, and 5 to 90% may be plasma cells; multiple myelomas are observed in some examples of plasma cell leukaemia, but discrete nodules are not formed in bone. Although there are other clinicopathologic differences in the two conditions, they may be phases of the same basic process. (05 Mar 2000) |
| murine leukaemia | A leukaemic disorder of mice caused by a number of different type C retroviruses. (05 Mar 2000) |
| murine leukaemia virus | <virology> A group of type C retroviruses infecting mice and causing in some strains lymphatic leukaemia after a long latent period. Nearly all are replication competemt and v onc minus. See: Abelson leukaemia virus. (18 Nov 1997) |
| myeloblastic leukaemia | A form of granulocytic leukaemia in which there are large numbers of myeloblasts in various tissues (and organs) and in the circulating blood; the immature forms may amount to 30 to 60% (or even a greater proportion) of the increased total number of white blood cells. Used synonymously for acute granulocytic leukaemia. Synonym: leukaemic myelosis. (05 Mar 2000) |
| myelocytic leukaemia | <haematology, tumour> A form of leukaemia characterised by an uncontrolled proliferation of myelopoietic cells in the bone marrow and in extramedullary sites, and the presence of large numbers of immature and mature granulocytic forms in various tissues (and organs) and in the circulating blood. The total count may range from 1000 (aleukaemic variety) to several hundred thousand per cu mm. The predominant cell is usually of the neutrophilic series, but, in a few instances, eosinophilic or basophilic granulocytes, or even megakaryocytes, may represent the chief form; early in granulocytic leukaemia, the circulating blood may contain excessive numbers of all of the granulocytic forms. Synonym: leukaemic myelosis, myelocytic leukaemia, myelogenic leukaemia, myelogenous leukaemia, myeloid leukaemia. (05 Mar 2000) |
| polymorphocytic leukaemia | Granulocytic leukaemia, especially any variety in which the predominant cells are mature, segmented granulocytes. (05 Mar 2000) |
| myelomonocytic leukaemia | A variant of granulocytic leukaemia with monocytosis in the peripheral blood. Synonym: Naegeli type of monocytic leukaemia. (05 Mar 2000) |
| hairy cell leukaemia | <haematology, oncology> A rare chronic disorder characterised by proliferation of hairy cells in reticuloendothelial organs and blood. Origin: Gr. Haima = blood (13 Nov 1997) |
| prolymphocytic leukaemia | <haematology> A variant of chronic lymphocytic leukaemia in which the malignant cells have a more immature appearance. The disease requires chemotherapy and/or radiotherapy and sometimes removal of the spleen (splenectomy). Origin: Gr. Haima = blood (13 Nov 1997) |
| Schilling type of monocytic leukaemia | See: monocytic leukaemia. (05 Mar 2000) |
| secondary leukaemia | A leukaemia arising from either previous chemotherapy or radiotherapy or as the development of a pre-existing condition, such as myelodysplasia. Origin: Gr. Haima = blood (13 Nov 1997) |
| human leukaemia-associated antigens | Antigen's on the surface of leukaemic cells which seem not to be present on the surfaces of the same type of normal cells; the myeloblast antigen of acute myelogenous leukaemia found in chronic myelogenous leukaemia is thought to be associated with a "blastic" transformation. (05 Mar 2000) |
| human T-cell leukaemia virus | <virology> One of a group of retroviruses which causes the disease T-cell leukaemia in humans. T-cell leukaemia is a type of the cancer leukaemia where the body uncontrollably produces large amounts of abnormal (nonworking) T lymphocytes. (09 Oct 1997) |
| human T-cell lymphoma/leukaemia virus | A group of viruses (subfamily Oncovirinae, family Retroviridae) that are lymphotropic with a selective affinity for the helper/inducer cell subset of T lymphocytes and that are associated with adult T-cell leukaemia and lymphoma. Synonym: human T-cell lymphotropic virus. (05 Mar 2000) |