| NICU | neonatal intensive care unit; neurological intensive care unit; neurosurgical intensive care unit; n... |
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| PCCM | pediatric critical care medicine; primary care case management; primary care case manager |
| PCP | parachlorophenate; patient care plan; pentachlorophenol; 1-(1-phenylcyclohexyl)piperidine; periphera... |
| PCU | pain control unit; primary care unit; patient care unit; pulmonary care unit |
| RC | an electronic circuit containing a resistor and capacitor in series; radiocarpal; reaction center; r... |
| combining site | <biochemistry, immunology> Any region of a molecule that binds or reacts with a given compound. Especially of the region of immunoglobulin that combines with the determinant of an appropriate antigen. (09 Jan 1998) |
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| placental site trophoblastic tumour | A tumour usually arising in the uterus of parous women during reproductive years. Histologically, the tumour consists of a predominance of intermediate trophoblastic cells with fibrinoid material and vascular invasion. (05 Mar 2000) |
| Con A binding site | <biochemistry> A common misuse of the term receptor. Con A binds to the mannose residues of many different glycoproteins and glycolipids and the binding is therefore not to a specific site. It could be argued that the receptor is the Con A and cells have Con A ligands on their surfaces: certainly this would be less confusing. (05 Jan 1998) |
| mucolipidosis III | <biochemistry> Mucolipidosis with mild Hurler-like symptoms, restricted joint mobility, short stature, mild mental retardation, and dysplastic skeletal changes, especially of the hip. Aortic and mitral valve disease are often present. It is associated with a deficiency of UDP-N-acetyl glucosamine and lysosomal enzyme N-acetylglucosaminyl-1-phosphotransferase. Inheritance: autosomal recessive. Synonym: pseudo-Hurler polydystrophy, pseudopolydystrophy. (05 Mar 2000) |
| mucopolysaccharidosis III | Mucopolysaccharidosis characterised by heparitin sulfate in the urine, progressive mental retardation, mild dwarfism, and other skeletal disorders. There are four clinically indistinguishable but biochemically distinct forms, each due to a deficiency of a different enzyme. (12 Dec 1998) |
| congenital antithrombin III deficiency | Antithrombin III is a protein which stimulates the removal of blood clots in the bloodstream. Small blood clots form normally within the bloodstream, but are normally dissolved via the bodys antithrombin III. The deficiency of antithrombin III will result in an increased risk for blood clot formation causing organ damage. This is an inherited as a autosomal dominant trait. Inheritance: autosomal dominant. (27 Sep 1997) |
| multiple cloning site | Region of a phage or plasmid vector that has been engineered to contain a series of restriction sites that are usually unique within the entire vector. This makes it particularly easy to insert or excise (subclone) DNA fragments. (18 Nov 1997) |
| connective tissue activating peptide III | Cytokine, produced from platelet basic protein, that acts as a growth factor. (18 Nov 1997) |
| mutagenesis, site-directed | Mutagenesis where the mutation is caused by in vitro induction directed at a specific site in a DNA molecule. The most common method involves use of a chemically synthesised oligonucleotide mutant which can hybridise with the DNA target molecule. The resulting mismatch-carrying DNA duplex may then be transfected into a bacterial cell line and the mutant strands recovered. (12 Dec 1998) |
| polycloning site | Region of a phage or plasmid vector that has been engineered to contain a series of restriction sites that are usually unique within the entire vector. This makes it particularly easy to insert or excise (subclone) DNA fragments. (18 Nov 1997) |
| mycinamicin III O-methyltransferase | <enzyme> Catalyses the incorporation of the methyl group of s-adenosyl-l-methionine at the 3'' position of mycinamicin III; from micromonospora griseorubida; genbank d16097 Registry number: EC 2.1.1.- Synonym: mycf gene product, miii o-mtase (26 Jun 1999) |
| cos site | <molecular biology> A 12-nucleotide bases-long segment of single stranded DNA that exists at both ends of the bacteriophage lambda's double-stranded genome. The two cos sites at the ends of the genome are complementary to one another so that the genome can become circular once the virus has infected a host bacterium. The circular genome can then be duplicated continuously until there are many repeats of it strung together, the cos sites show the virus where to cut them apart right before they are packaged into individual capsids as new progeny viruses ready to infect more host cells. (10 Nov 1998) |
| cranial mononeuropathy III | (compression type) A disorder involving vision changes and eyelid drooping associated with a decreased functioning of cranial nerve III. Damage is usually caused by compression of the nerves from localised lesions or a swelling in the area of the nerve. Examples include cerebral aneurysms and tumours Symptoms include a drooping eyelid and double vision. (diabetic type) A disorder involving vision changes and eyelid drooping associated with a decreased functioning of cranial nerve III as a complication of diabetes. Symptoms include a drooping eyelid and double vision. Good control of blood sugars can reduce the incidence of this complication. (27 Sep 1997) |
| cranial nerve III | <anatomy, nerve> The occulomotor nerve is responsible for motor enervation of upper eyelid muscle, extraocular muscle and pupillary muscle. Lesions of the oculomotor nerve results in ptosis (dropping eyelid), deviation of the eyeball outward, double vision and a dilated pupil. Synonym: cranial nerve III. (27 Sep 1997) |
| privileged site | An anatomic area lacking lymphatic drainage, such as the brain, cornea, and hamster cheek pouch, in which heterologous tumours may grow because the host does not become sensitised. (05 Mar 2000) |