| focal sclerosis with hyalinosis | <nephrology> A kidney disorder that results in fibrosis and scarring in the kidney glomerulus. The cause is unknown but some cases can result from reflux nephropathy. The clinical manifestation of this kidney disorder is nephrotic syndrome. Symptoms include weight gain, swelling, hypertension and foamy urine. High blood cholesterol and triglyceride levels are also seen with this disorder. Treatment has included the use of corticosteroids and immunosuppressives. Antihypertensive agents and diuretics may also be necessary. Over one-half will develop chronic renal failure within 10 years of diagnosis. (27 Sep 1997) |
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| laminar cortical sclerosis | A degeneration of nerve fibres in the corona radiata in a laminar pattern. (05 Mar 2000) |
| lateral spinal sclerosis | Considered by many to be a subgroup of motor neuron disease; a slowly progressive degenerative disorder of the motor neurons of the cerebral cortex, resulting in widespread weakness on an upper motor neuron basis; spasticity, hyperreflexia, and Babinski signs are present, but not fasciculation potentials, nor any electrodiagnostic evidence of a lower motor neuron lesion. Synonym: lateral spinal sclerosis. (05 Mar 2000) |
| lobar sclerosis | Circumscribed atrophy of the cerebral cortex. Synonym: lobar sclerosis, progressive circumscribed cerebral atrophy. (05 Mar 2000) |
| aphasia, primary progressive | A type of aphasia appearing gradually and gradually worsening without any major change in other cognitive functions. It is regarded by some authors as a syndrome which may be due to various degenerative diseases of the cerebral cortex (notably alzheimer disease, owing to its frequency), while others see in it an autonomous disease related to a neuropathological process that is distinct from the main degenerative dementias. The principal clinical peculiarity of primary progressive aphasia is that it spares the patient's autonomy for a long time, but ultimately turns into global dementia. (12 Dec 1998) |
| bovine progressive degenerative myeloencephalopathy | A familiar myeloencephalopathy of brown Swiss cattle characterised by bilateral hindleg weakness and ataxia and deficient proprioceptive reflexes. (05 Mar 2000) |
| rapidly progressive glomerulonephritis | <nephrology> A relatively uncommon (affecting 1 out of 10,000 people) form of acute glomerulonephritis that results in damage within the glomerulus of the kidney. There is rapid loss of kidney function with the formation of crescents on microscopic analysis (kidney biopsy). This disorder may result in acute glomerulonephritis or nephrotic syndrome, but ultimately results in renal failure and end-stage renal disease. Symptoms include smoky coloured urine (pyuria), decreased urine output, swelling and hypertension. Any conditions which can cause a vasculitis increase the risk of this disorder. Some examples include lupus, Goodpasture's syndrome, Henoch-Schonlein purpura, IgA nephropathy, membranoproliferative glomerulonephritis, anti-glomerular basement membrane antibody disease, history for malignant tumours and exposure to hydrocarbon solvents. (27 Sep 1997) |
| pneumonia, progressive interstitial, of sheep | Chronic respiratory disease caused by the visna-maedi virus. It was formerly believed to be identical with jaagsiekte (pulmonary adenomatosis, ovine) but is now recognised as a separate entity. (12 Dec 1998) |
| primary progressive cerebellar degeneration | A familial ataxic condition related to cerebellar degeneration. (05 Mar 2000) |
| progressive | Advancing, going forward, going from bad to worse, increasing in scope or severity. (18 Nov 1997) |
| progressive bacterial synergistic gangrene | Undermining ulcer of the skin and subcutaneous tissues, usually following an operation, caused by a synergistic interaction between microaerophilic nonhemolytic streptococci and aerobic haemolytic staphylococci. Synonym: Meleney's gangrene, progressive bacterial synergistic gangrene. (05 Mar 2000) |
| progressive bulbar palsy | One of the subgroups of motor neuron disease; a progressive degenerative disorder of the motor neurons of primarily the brainstem, manifested as weakness (and wasting) of the various bulbar muscles, resulting in dysarthria and dysphagia-fluid regurgitation is an outstanding symptom and can cause aspiration; tongue weakness and wasting is usually evident, and often the fasciculation potentials are present in the tongue and facial muscles. Synonym: glossopalatolabial paralysis, glossopharyngeolabial paralysis. (05 Mar 2000) |
| progressive bulbar paralysis | Progressive weakness and atrophy of the muscles of the tongue, lips, palate, pharynx, and larynx, usually occurring in later life; most often caused by motor neuron disease. Synonym: bulbar palsy, bulbar paralysis, Duchenne's disease, Erb disease, glossolabiolaryngeal paralysis, glossolabiopharyngeal paralysis. (05 Mar 2000) |
| progressive cataract | A cataract in which the opacification process progresses to involve the entire lens. (05 Mar 2000) |
| progressive cerebellar tremor | <syndrome> An intention tremor beginning in one extremity, gradually increasing in intensity, and subsequently involving other parts of the body. Synonym: progressive cerebellar tremor. Facial paralysis, otalgia, and herpes zoster resulting from viral infection of the seventh cranial nerve and geniculate ganglion, a form of juvenile paralysis agitans associated with primary atrophy of the pallidal system. Synonym: paleostriatal syndrome, pallidal syndrome. Synonym: Ramsay Hunt's syndrome. (05 Mar 2000) |