| mitotic rate | The proportion of cells in a tissue that are undergoing mitosis, expressed as a mitotic index or, roughly, as the number of cells in mitosis in each microscopic high-power field in tissue sections. (05 Mar 2000) |
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| mitotic recombination | <genetics, molecular biology> Somatic crossing over. Crossing over can occur between homologous chromosomes during mitosis, but is very rare because the chromosomes do not normally pair. When it occurs it can lead to new combinations of previously linked genes. Although infrequent, mitotic recombination has been utilised for genetic analysis in Aspergillus and in studies on developmental compartments in Drosophila where the frequency of mitotic recombination can be increased by X irradiation. (18 Nov 1997) |
| mitotic segregation | <genetics> Mitotic recombination. (18 Nov 1997) |
| mitotic shake off method | <cell biology, procedure> A method of collecting cells in mitosis, so that the chromosomes can be examined and the karyotype determined. Many cultured cells round up during mitosis and so become less firmly attached to the culture substratum. Cells in mitosis thus can be removed into suspension by gentle shaking of the culture vessel, leaving the nonmitotic cells still attached. The number of cells that are in mitosis is usually increased by using a drug, such as colcemid that blocks mitosis at metaphase. (18 Nov 1997) |
| mitotic spindle | See: spindle and mitosis. (18 Nov 1997) |
| mitotic spindle apparatus | An organelle consisting of three components: 1) the astral microtubules, which form around each centrosome and extend to the periphery; 2) the polar microtubules which extend from one spindle pole to the equator; and 3) the kinetochore microtubules, which connect the centromeres of the various chromosomes to either centrosome. (12 Dec 1998) |
| mitoxantrone | <chemical> An anthracenedione antineoplastic agent. It is particularly effective against advanced breast cancer, acute leukaemia, and malignant lymphoma. It has mild side effects, especially with respect to nausea, vomiting, hair loss, and cardiotoxicity. Pharmacological action: analgesics, antineoplastic agent. Chemical name: 9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl)amino)ethyl)amino)- (12 Dec 1998) |
| mitoxantrone hydrochloride | 1,4-Dihydro-5,8-bis[[2-[2-hydroxyethyl)-amino]ethyl]anthraquinone dihydrochloride;a synthetic anti-neoplastic used intravenously in the initial therapy for acute nonlymphocytic leukaemia in adults. (05 Mar 2000) |