| MEL | a cell in the basal layer of the epidermis that produces melanin under the control of the melanocyte-stimulating hormone |
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| MEL | a hormone secreted by the anterior pituitary gland that controls the degree of pigmentation in melanocytes |
| MEL | abnormally dark skin caused by increased deposits of melatonin |
| MEL | haddock |
| MEL | important food fish on both sides of the Atlantic |
| MEL | any of several malignant neoplasms (usually of the skin) consisting of melanocytes |
| MEL | New World migratory locusts and common American grasshoppers |
| MEL | a condition characterized by abnormal deposits of melanin (especially in the skin) |
| MEL | a genus of Mimidae |
| MEL | mockingbird of Mexico |
| MEL | one of many subfamilies into which some classification systems subdivide the Liliaceae but not widely accepted: includes Aletris |
| MEL | a tan discoloration of a woman's face that is associated with pregnancy or with the use of oral contraceptives |