| total necrosis | Complete necrosis of the cytologic and histologic elements in a portion of tissue, as in caseous necrosis, death of an entire organ or part. (05 Mar 2000) |
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| epiphysial aseptic necrosis | Aseptic necrosis of bony epiphyses, probably due to ischemia; it may affect the upper end of the femur (Legg-Calve-Perthes disease), the tibial tubercle (Osgood-Schlatter disease), the tarsal navicular bone or the patella (Kohler's disease), the second metatarsal head (Freiberg's disease), vertebral bodies (Scheuermann's disease), or the capitellum of the humerus (Panner's disease). (05 Mar 2000) |
| tumor necrosis factor | <cytokine> Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997) |
| tumour necrosis factor | <cytokine> Originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette-Guerin. Preferentially kills tumour cells in vivo and in vitro, causes necrosis of certain transplanted tumours in mice and inhibits experimental metastases. Human Tumour Necrosis factor alpha is a protein of 157 amino acids and has a wide range of pro inflammatory actions. Usually considered a cytokine. Synonym: cachectin. Acronym: TNF (13 Nov 1997) |
| tumour necrosis factor-beta | <cytokine> A cytolytic factor that is produced by CD4 and CD8 T-cells after their exposure to an antigen. (05 Mar 2000) |
| kidney cortex necrosis | The death of all the functioning renal cells of the kidney cortex with continued viability of the majority of the medullary units. It is due usually to the arterial distribution peculiar to the kidney which makes the renal cortex more susceptible to diminished blood flow. (12 Dec 1998) |
| kidney papillary necrosis | A form of acute kidney disease characterised by necrosis of the renal papillae. It is most frequently associated with diabetes mellitus because of the severe vascular disease present in the arteries and capillaries, particularly in the kidney. There is usually a large component of infection present, and in non-diabetics pyelonephritis and obstructive uropathy are the usual aetiologic agents. (12 Dec 1998) |
| kidney tubular necrosis, acute | Acute kidney failure resulting from destruction of tubular epithelial cells. It is commonly attributed to exposure to toxic agents or renal ischemia following severe trauma. (12 Dec 1998) |
| fat necrosis | A condition in which the neutral fats in the cells of adipose tissue are split into fatty acids and glycerol. (12 Dec 1998) |
| fat necrosis tumour | <surgery> Destruction of fat cells in the breast due to trauma or injury that can cause a hard noncancerous lump. (09 Oct 1997) |
| Zenker's necrosis | A form of severe hyaline degeneration or necrosis in skeletal muscle, occurring in severe infections. Synonym: waxy degeneration, Zenker's necrosis. (05 Mar 2000) |
| zonal necrosis | Necrosis predominantly affecting or limited to an anatomical zone, especially parts of the hepatic lobules defined according to proximity to either the portal tracts or central (hepatic) veins. (05 Mar 2000) |
| femur head necrosis | Aseptic or avascular necrosis of the femoral head. The major types are idiopathic (primary), as a complication of fractures or dislocations, and legg-perthes disease. (12 Dec 1998) |
| fibrinoid necrosis | Necrosis in which the necrotic tissue has some staining reactions resembling fibrin and becomes deeply eosinophilic, homogenous, and refractile. (05 Mar 2000) |
| focal necrosis | Occurrence of numerous, relatively small or tiny, fairly well-circumscribed, usually spheroidal portions of tissue that manifest coagulative, caseous, or gummatous necrosis and are characteristically associated with agents that are haematogenously disseminated; frequently observed only in histologic sections, but the foci may be as large as 1 to 3 mm and macroscopically visible; arbitrarily, foci larger than that are usually not termed focal necrosis. (05 Mar 2000) |