| adenosine tetraphosphate | A condensation product of adenosine with tetraphosphoric acid at the 5' position. (05 Mar 2000) |
|---|---|
| adenosine triphosphatase | <enzyme> A group of enzymes which catalyze the hydrolysis of ATP coupled with another function such as transporting calcium across a membrane. These enzymes may be dependent on calcium, magnesium, anions, h+, or DNA. Chemical name: ATP phosphohydrolase Registry number: EC 3.6.1.3 (12 Dec 1998) |
| adenosine triphosphate | <biochemistry> A nucleotide present in all living cells which serves as an energy source for many metabolic processes and is required for ribonucleic acid synthesis. (06 May 1997) |
| rRNA (adenosine-O-2'-)methyltransferase | <enzyme> Forms 2'-o-methyladenosine; ermd protein methylates a specific residue on 23s rrna to confer macrolide-lincosamide-streptogramin b resistance; emre specifically modifies 23s rrna by n6,n6-dimethylation of a2058; has been sequenced; genbank x82668 (emrc) Registry number: EC 2.1.1.66 Synonym: rrna(adenine-2-)methyltransferase, ribosomal RNA methylase, rrna methylase, ermd gene product, ermc' gene product, 23s ribosomal RNA a1067 2'-methyltransferase, 23s rrna methylase, ermsf methyltransferase, tlra methyltransferase, thiostrepton-resistance methylase, thiostrepton-resistance-encoding gene product, tsnr gene product, erme methyltransferase, 23s ribosomal RNA a2058 methyltransferase, ermc methyltransferase, ermam methyltransferase (26 Jun 1999) |
| poly adenosine diphosphate ribose | <chemical> A polynucleotide formed from NAD in the presence of NAD+ nucleosidase. Chemical name: Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose, homopolymer (12 Dec 1998) |
| 7-(adenosine-5-pyrophosphoryl)-D-sedoheptulose synthase | <enzyme> Transketolase-like enzyme; adpribose and fructose-6-phosphate yields 7-(adenosine-5'-pyrophosphoryl)-d-sedoheptulose Registry number: EC 2.2.- (26 Jun 1999) |
| 8-bromo cyclic adenosine monophosphate | <chemical> 8-bromoadenosine cyclic 3',5'-(hydrogen phosphate). A long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase, but resistant to degradation by cyclic AMP phosphodiesterase. Chemical name: Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate) (12 Dec 1998) |
| abdominal muscle deficiency syndrome | <syndrome> Congenital absence (partial or complete) of abdominal muscles, in which the outline of the intestines is visible through the protruding abdominal wall; in males, genitourinary anomalies (urinary tract dilation and cryptorchidism) are also found; genetics unclear. (05 Mar 2000) |
| adult lactase deficiency | Onset of lactase deficiency, with resulting milk intolerance and malabsorption, in adulthood. Inherited forms may not be manifested until adulthood; any process that damages the intestinal lining cells can cause lactase deficiency in adults. (05 Mar 2000) |
| alpha-1 antitrypsin deficiency | <chest medicine> Deficiency of the protease inhibitor alpha-1 antitrypsin, leads primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. The lack of this protein leads to damage of various organs, but mainly to the lung and liver. symptoms may become apparent at a very early age or in adulthood, manifesting either as shortness of breath or liver related symptoms (jaundice, fatigue, fluid in the abdomen, mental changes, or gastrointestinal bleeding). There are several options for treatment of the lung disease, including replacement of the missing protein. Treatment of the liver disease is a well-timed liver transplant (12 Dec 1998) |
| alpha-1-proteinase deficiency | Absence of a serum proteinase inhibitor that may cause nodular non-suppurative panniculitis. (05 Mar 2000) |
| alpha-antitrypsin deficiency | <enzyme> A specific enzyme (alpha 1 antitrypsinase) that when absent genetically can result in panacinar emphysema (lung disease) and liver disease. There is no specific treatment for this condition other than supportive care for the liver and lung complications. Medications such as alpha-1proteinase inhibitor is given regularly to these patients. Incidence: approximately 1 in 10,000. (02 Jan 1998) |
| anaemia, iron deficiency | Deficiency of iron results in anaemia because iron is necessary to make haemoglobin, the key molecule in red blood cells responsible for the transport of oxygen. In iron deficiency anaemia, the red cells are unusally small (microcytic) and pale (hypochromic). Characteristic features of iron deficiency anaemia in children include failure to thrive (grow) and increased infections. The treatment of iron deficiency anaemia, whether it be in children or adults, is with iron and iron-containing foods. Food sources of iron include meat, poultry, eggs, vegetables and cereals (especially those fortified with iron). According to the National Academy of Sciences, the Recommended Dietary Allowances of iron are 15 milligrams per day for women and 10 milligrams per day for men. Anaemia characterised by low or absent iron stores, low serum iron concentration, elevated free erythrocyte porphorin, low transferrin saturation, elevated transferrin, low serum ferritin, low haemoglobin concentration or haematocrit, and hypochromic microcytic red blood cells. Symptoms may include pallor, angular stomatitis and other oral lesions, gastrointestinal complaints, retinal haemorrhages and exudates, and thinning and brittleness of the nails. Among the causes of iron-deficiency anaemia are inadequate iron intake, impaired iron absorption, increased blood loss and increased requirements such as infancy, pregnancy, and lactation. (12 Dec 1998) |
| antibody deficiency disease | <syndrome> Any of a group of disorders associated with a defective antibody production due to defects in the B-type lymphocyte system or in T-type lymphocytes; chief manifestation is an increased susceptibility to infection by various microorganisms. See: agammaglobulinaemia, hypogammaglobulinaemia, immunodeficiency. Synonym: antibody deficiency disease. (05 Mar 2000) |
| antibody deficiency syndrome | <syndrome> Any of a group of disorders associated with a defective antibody production due to defects in the B-type lymphocyte system or in T-type lymphocytes; chief manifestation is an increased susceptibility to infection by various microorganisms. See: agammaglobulinaemia, hypogammaglobulinaemia, immunodeficiency. Synonym: antibody deficiency disease. (05 Mar 2000) |