| cyclin | <protein> Proteins (A and B forms known) whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are though to drive cells into G2 phase and thus to mitosis. Cyclins combine with p34 kinase (cdc2) to form maturation-promoting factor (MPF). See: M phase promoting factor. (18 Nov 1997) |
|---|---|
| cyclin a | A 33-kD protein identical to adenovirus e1a-associated protein p60. Cyclin a regulates p33cdk2 and p34cdc2, and is necessary for progression through the s phase of the cell cycle. (12 Dec 1998) |
| cyclin b | A 58-kD protein that is regulated post-transcriptionally and post-translationally in the cell cycle. (12 Dec 1998) |
| cyclin d1 | Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin d1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms. (12 Dec 1998) |
| cyclin e | A 50-kD protein that complexes with cdk2 in the late g1 phase of the cell cycle. (12 Dec 1998) |
| cyclin E-dependent kinase | <chemical> Synonym: cyce-h1k, cyce-dependent h1 kinase (26 Jun 1999) |
| cyclin-dependent kinases | Protein kinases that control cell cycle progression in all eukaryotes and require physical association with cyclins to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (12 Dec 1998) |
| cyclins | Regulatory proteins that function in the cell cycle to activate maturation-promoting factor. They complex with p34cdc2 (protein p34cdc2), the catalytic subunit of maturation-promoting factor, and modulate its protein kinase activity. Cyclins themselves have no enzymatic activity. (12 Dec 1998) |
| cyclitis | Inflammation of the ciliary body. Origin: G. Kyklos, circle (ciliary body), + -itis, inflammation (05 Mar 2000) |
| cyclization | Changing an open-chain hydrocarbon to a closed ring. (12 Dec 1998) |
| cyclizine | <chemical> A histamine h1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. Pharmacological action: antiemetics, histamine h1 antagonists. Chemical name: Piperazine, 1-(diphenylmethyl)-4-methyl- (12 Dec 1998) |
| cyclizine hydrochloride | 1-Diphenylmethyl-4-methylpiperazine hydrochloride;an antihistamine agent useful in the prevention and relief of motion sickness and symptoms caused by vestibular disorders. (05 Mar 2000) |
| cyclizine lactate | An agent with the same use and action as the hydrochloride. (05 Mar 2000) |
| cyclo- | 1. Combining forms relating to a circle or cycle; or denoting an association with the ciliary body. 2. In chemistry, a combining form indicating a continuous molecule, without end, or the formation of such a structure between two parts of a molecule. Origin: G. Kyklos, circle (05 Mar 2000) |
| cyclobenzaprine hydrochloride | 1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-diemthyl-, hydrochloride;a centrally acting skeletal muscle relaxant used to relieve acute muscular spasms. (05 Mar 2000) |