| coarctation of the aorta | <cardiology, embryology, paediatrics> A congenital heart defect that results in the narrowing of the lumen of the aorta. The narrowing occurs most often distal to the origin of the left subclavian artery. Coarctation occurs in approximately 7% of patients with congenital heart disease and is twice as common in males. Surgical correction is most often required. Symptoms include headaches, dizziness, fainting, nosebleeds, diminished pulses in lower extremities and muscle cramps in legs with activity. There may be no symptoms in some individuals. (27 Sep 1997) |
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| coarctectomy | Excision of a coarctation (of the aorta). (05 Mar 2000) |
| coarctotomy | Division of a stricture. Origin: coarct + G. Tome, cutting (05 Mar 2000) |
| coarse breast architecture | <radiology> Inflammatory carcinoma, other lymphatic spread of tumour, oedema, congestive heart failure, uraemia, drug-induced, radiation, mastitis (12 Dec 1998) |
| coarse dispersion | 1. A condition of temporary cessation, as of animation, of pain or of any vital process. 2. <pharmacology> A preparation of a finely divided drug intended to be incorporated (suspended) in some suitable liquid vehicle before it is used or already incorporated in such a vehicle. Origin: L. Suspensio (18 Nov 1997) |
| coarse tremor | A tremor in which the amplitude is large and the oscillations are usually irregular and slow. (05 Mar 2000) |
| CoAS- | Symbols for the coenzyme A radical and reduced coenzyme A, respectively. (05 Mar 2000) |
| coat | 1. The outer covering or envelope of an organ or part. 2. One of the layers of membranous or other tissues forming the wall of a canal or hollow organ. See: tunic. (05 Mar 2000) |
| coat protein | <protein> The proteins which make up the outer coat of a virus (called the capsid). (09 Oct 1997) |
| coated pit | <biology> First stage in the formation of a coated vesicle. (18 Nov 1997) |
| coated pits, cell-membrane | Specialised regions of the cell membrane composed of pits coated with a bristle covering made of the protein clathrin. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalised into the cytoplasm to form the coated vesicles. (12 Dec 1998) |
| coated tongue | A tongue with a whitish layer on its upper surface, composed of epithelial debris, food particles, and bacteria; often an indication of indigestion or of fever. Synonym: furred tongue. (05 Mar 2000) |
| coated vesicle | <cell biology> Vesicle formed as an invagination of the plasma membrane (a coated pit) and that is surrounded by a basket of clathrin. Associated with receptor mediated pinocytosis and receptor recycling. (18 Nov 1997) |
| coated vesicles | Vesicles formed when cell-membrane coated pits (coated pits, cell-membrane) invaginate and pinch off. The outer surface of these vesicles is covered with a lattice-like network of the protein clathrin. Shortly after formation, however, the clathrin coat is removed and the vesicles are referred to as endosomes. (12 Dec 1998) |
| coating | A covering; a layer of some substance spread over a surface. (05 Mar 2000) |