| CD8 | <immunology> Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. Cd8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in major histocompatibility complex class I-restricted interactions. (12 Dec 1998) |
|---|---|
| CD8 cell | <immunology> One type of T-lymphocyte which bears the CD8 molecular marker on its surface. Some CD8 cells recognise and kill cancerous cells and those infected by intracellular pathogens (some bacteria, viruses and mycoplasma). These cells are called cytotoxic T-lymphocytes (see). (09 Oct 1997) |
| CD8-positive T-lymphocytes | A critical subpopulation of regulatory T-lymphocytes involved in MHC class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-lymphocytes, cytotoxic) and suppressor T-lymphocytes (T-lymphocytes, suppressor-effector). (12 Dec 1998) |
| CD80 | <immunology> The natural ligand for the T-cell antigen CD28 (antigens, CD28) mediating t-cell and B-cell adhesion. Cd80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and ctla-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production. (12 Dec 1998) |
| CD95 | <immunology> Differentiation antigens expressed on a variety of cell lines including myeloid and lymphoblastoid cell lines. Their primary role is to regulate peripheral immune responses, which is achieved by triggering apoptosis. (12 Dec 1998) |
| CDC | The Centres for Disease Control and Prevention (CDC). The American agency charged with tracking and investigating public health trends. Its stated mission is To promote health and quality of life by preventing and controlling disease, injury, and disability. A part of the U.S. Public Health Services (PHS) under the Department of Health and Human Services (HHS), the CDC is based in Atlanta, Georgia. It publishes key health information including weekly data on all deaths and diseases reported in the United States ( Morbidity and Mortality Weekly Report ) and travelers' health advisories. (12 Dec 1998) |
| cdc gene | <molecular biology> Cell division cycle genes, of which many have now been defined, especially in yeasts. See cyclin. (18 Nov 1997) |
| cdc2+-CDC28-related protein kinase | <enzyme> From rice; key enzyme for cell cycle regulation in eukaryocytes; belongs to serine-threonine kinase subfamily Registry number: EC 2.7.10.- Synonym: cdc2-cdc28-pk, cdc2-cdc28-rp kinase (26 Jun 1999) |
| cdc28 protein kinase | <enzyme> A protein kinase encoded by the saccharomyces cerevisiae cdc28 gene and required for progression from the g1 to the s phase in the cell cycle. It is a complex of approximately 160 kD containing a substrate called p40. Registry number: EC 2.7.1.- (12 Dec 1998) |
| Cdc42Hs-associated kinase | <enzyme> Specifically binds cdc42hs in its GTP-bound form; 379 aa residues, mw 45 kD; aa sequence given in first source Registry number: EC 2.7.1.- (26 Jun 1999) |
| CDC5 protein kinase | <enzyme> Phosphorylates the residues that play a crucial role in mitotic function; genes msd2 and cdc5 are identical; 705 aa residues, mw 81 kD genbank m84220 Registry number: EC 2.7.1.- Synonym: cdc5 gene product (26 Jun 1999) |
| CDC7 protein kinase | <enzyme> From saccharomyces cerevisiae; amino acid sequence has been determined; human cdc7 (hucdc7) is genbank ab003698; xenopus cdc7 (xecdc7) is genbank ab003699 Registry number: EC 2.7.1.- Synonym: cdc7 gene product, hucdc7, xecdc7 (26 Jun 1999) |
| CDE antigens | rh blood group |
| CDE blood group | See Rh blood group, Blood Groups appendix. (05 Mar 2000) |
| cDNA | <molecular biology> DNA that is synthesised from a messenger RNA template, the single-stranded form is often used as a probe in physical mapping to locate the gene or can be cloned in the double stranded form. Viral reverse transcriptase can be used to synthesise DNA that is complementary to RNA (for example an isolated mRNA). Acronym: cDNA (13 Nov 1997) |