| E* | lesion on the erythrocyte cell membrane at the site of complement fixation |
|---|---|
| FMR | fragile site mental retardation [syndrome]; Friend-Moloney-Rauscher [antigen] |
| fra | fragil [site] |
| FRAXE | X-linked mental retardation-fragile site [syndrome] |
| HBVS | hepatitis B virus integration site |
| site-specific mutagenesis | <cell culture, molecular biology> An in vitro technique in which an alteration is made at a specific site in a DNA molecule, which is then reintroduced into a cell. Various techniques are used, for the cell biologist, a very powerful approach to determining which parts of a protein or nucleotide sequence are critical to function. (18 Nov 1997) |
|---|---|
| site specific mutation | An alteration of the structure of a gene at a specific sequence, usually referring to experimentally produced changes in gene sequence. (05 Mar 2000) |
| site-specific recombination | <molecular biology> A type of recombination that occurs between two specific short DNA sequences present in the same or in different molecules. An example is the integration and excision of _ prophage. (18 Nov 1997) |
| special aquatic site | Those sites identified in 40 CRF 230, Subpart E (i.e., sanctuaries and refuges, wetlands, mud flats, vegetated shallows, coral reefs, and riffle and pool complexes). They are geographic areas, large or small, possessing special ecological characteristics of productivity, habitat, wildlife protection, or other important and easily disrupted ecological values. These areas are generally recognised as significantly influencing or positively contributing to the general overall environmental health or vitality of the entire ecosystem of a region. Source: Environmental Protection Agency, 40 CFR |
| neoplasms by site | A collective term for precoordinated organ/neoplasm headings locating neoplasms by organ, as brain neoplasms, duodenal neoplasms, liver neoplasms, etc. (12 Dec 1998) |
| switching site | The break point in a DNA sequence at which a gene segment unites with another gene segment, as in the production of the immunoglobulins. (05 Mar 2000) |
| deoxyribonucleases, type III site-specific | <enzyme> Enzyme systems composed of two subunits and requiring ATP and magnesium for endonucleolytic activity; they do not function as atpases. They exist as complexes with modification methylases of similar specificity. The systems recognise specific short DNA sequences and cleave a short distance, about 24 to 27 bases, away from the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.5 (12 Dec 1998) |
| deoxyribonucleases, type II site-specific | <enzyme> Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognise specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.4 (12 Dec 1998) |
| deoxyribonucleases, type I site-specific | <enzyme> Enzyme systems containing three different subunits and requiring ATP, s-adenosylmethionine, and magnesium for endonucleolytic activity to give random double-stranded fragments with terminal 5'-phosphates. They function also as DNA-dependent atpases and modification methylases, catalyzing the reactions of EC 2.1.1.72 and EC 2.1.1.73 with similar site-specificity. The systems recognise specific short DNA sequences and cleave at sites remote from the recognition sequence. Enzymes from different microorganisms with the same specificity are called isoschizomers. Registry number: EC 3.1.21.3 (12 Dec 1998) |
| DNA-(apurinic or apyrimidinic site) lyase | <enzyme> Formerly EC 3.1.25.2 Registry number: EC 4.2.99.18 Synonym: endodeoxyribonuclease (apurinic or apyrimidinic), apurinic endonuclease, apurinic DNA endonuclease, purine insertase, endonuclease iv, DNA repair endonuclease, endonuclease vi, endonuclease iv, E coli, bap1, bovine ap endonuclease I, nfo gene product, apci, apcii, apciii, ap lyase, ap endonuclease, hap1 DNA repair enzyme, apurine-apyrimidine endonuclease (26 Jun 1999) |
| DNAse i hypersensitivity site | <molecular biology> A site on a DNA molecule that is especially prone to being cut apart by the endonuclease enzyme DNase I, which breaks down DNA into smaller fragments by cleaving phosphodiester bonds. These sites tend to be near active genes, which are regularly transcribed. (09 Oct 1997) |
| trophoblastic tumour, placental site | A tumour that arises from the trophoblast of the placental bed and is composed mainly of cytotrophoblastic cells. It encompasses lesions of low- and high-grade malignancy. (holland et al., cancer medicine, 3d ed, p1691) (12 Dec 1998) |
| expression site | The location in the genome of the gene for the variable surface glycoprotein that is currently being expressed (an expression-linked copy) by the trypanosome (a parasitic protozoan which causes the disease African sleeping sickness). most of these sites are near the ends, or telomeres, of a chromosome. (09 Oct 1997) |
| upstream activation site | A DNA sequence that regulates transcription like an enhancer but does notwork if its located downstream from a promoter. (09 Oct 1997) |
| fragile site | Places on chromosomes that tend to break more often than other places. These places also tend to be where chromosomal translocations (a type of chromosomal mutation) occur. (09 Oct 1997) |