| 5α-r. |
an enzyme that catalyzes the irreversible reduction of testosterone to dihydrotestosterone with NADPH as the hydrogen donor. Deficiency of the enzyme, with resultant deficiency in dihydrotestosterone, is an autosomal recessive condition characterized by male pseudohermaphroditism, prepubertal ambiguous or female-type external genitalia (usually some form of perineal hypospadias), and some masculinization at puberty without gynecomastia.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 5,10-methenyltetrahydrofolate |
a substituted derivative of tetrahydrofolate, carrying a methylidyne group; it is formed in histidine degradation and in the interconversion of various folates, linking the flow of activated one-carbon units from serine and thymidylate synthesis with purine synthesis and the liver enzyme system for discarding excess single carbons.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 5,10-methenyltetrahydrofolate synthetase |
5-formyltetrahydrofolate cyclo-ligase.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 5,10-methylenetetrahydrofolate |
a doubly methylated, reduced derivative of folic acid occurring as an intermediate in the transfer of methyl groups to methionine, receiving them from formaldehyde, serine, and glycine.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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| 5,10-methylenetetrahydrofolate reductase (FADH2) |
[EC 1.7.99.5] an enzyme of the oxidoreductase class that catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahdyrofolate, using FADH2 and NADH as primary and secondary electron donors, respectively. The reaction is the means by which methyl groups are generated de novo for methylation reactions. Deficiency of the enzyme, an autosomal recessive trait, results in homocystinuria due to deficiency of 5-methyltetrahydrofolate–homocysteine S-methyltransferase; hypomethioninemia and neurologic abnormalities are present but megaloblastic anemia is absent.
출처: www.mercksource.com/pp/us/cns/cns_health_library.j...
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