| ATN | acute tubular necrosis; augmented transition network |
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| AVN | acute vasomotor nephropathy; atrioventricular nodal [conduction]; atrioventricular node; avascular n... |
| AVNFH | avascular necrosis of the femoral head |
| BARN | bilateral acute retinal necrosis |
| BCN | basal cell nevus; bilateral cortical necrosis |
pressure necrosis
| toxic shock syndrome | <syndrome> A blood-borne bacterial infection caused by the genus Staphylococcus. Usually effects menstruating females under the age of thirty and was associated in the past with the use of a particular type of tampon (no longer used). Common symptoms include: fever, chills, vomiting, sore throat, headache and decreased urine output. Progression of disease can result in lowering of blood pressure (shock) and renal failure. Treatment includes hospitalisation and intravenous antibiotics emergently. (27 Sep 1997) |
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| toxic substances | A chemical or mixture of chemicals that presents a high risk of injury to human health or to the environment. (05 Dec 1998) |
| toxic tetanus | Tonic spasms caused by strychnine or other tetanic. Synonym: toxic tetanus. (05 Mar 2000) |
| toxic unit | A unit formerly synonymous with minimal lethal dose but which, because of the instability of toxins, is now measured in terms of the quantity of standard antitoxin with which the toxin combines. See: L doses, minimal lethal dose. Synonym: toxin unit. (05 Mar 2000) |
| epidermal necrolysis, toxic | An exfoliative disease of skin seen primarily in adults and characterised by flaccid bullae and spreading erythema so that the skin has the appearance of being scalded. It results primarily from a toxic reaction to various drugs, but occasionally occurs as a result of infection, neoplastic conditions, or other exposure. (12 Dec 1998) |
| acute tubular necrosis | <nephrology> A kidney disorder that results in damage to the renal tubule cells leading to acute renal failure. Acute tubular necrosis can result from any condition which deprives the kidney of oxygen (ischaemia). Acute tubular necrosis may occur as a complication of shock, trauma or sepsis. Conditions such as diabetes or liver disease can predispose people to the development of acute tubular necrosis. Certain medications (for example aminoglycosides, amphotericin B, cyclosporine) are known to cause acute tubular necrosis as a toxic side effect. Radiopaque contrast dyes, used in some radiologic procedures, may also result in acute tubular necrosis as a rare complication from contrast dye use. Acronym: ATN (13 Nov 1997) |
| aseptic necrosis | <orthopaedics, pathology> Condition in which poor blood supply to an area of bone leads to bone death. Also called avascular necrosis and osteonecrosis. (12 Dec 1998) |
| avascular necrosis | <radiology> Aetiology (PLASTIC RAGS): P pancreatitis, L lupus, A alcohol, S steroids, T trauma, I idiopathic, infection, C caisson disease, collagen vascular disease, R radiation, rheumatoid arthritis, A amyloid, G Gaucher disease, S sickle cell disease findings: sclerosis, crescent sign, collapse (e.g., of femoral head) see also: staging (12 Dec 1998) |
| avascular necrosis staging | <radiology> Stage CT/X-ray bone scan I - cold/hot spot II sclerotic focus with osteopenic ring III crescent sign (subchondral lucency) IV articular collapse flattening of femoral head sensitivity 86% 78% specificity 79% 75% see also: avascular necrosis (AVN) (12 Dec 1998) |
| bridging hepatic necrosis | Area of liver necrosis which bridges adjacent portal areas and central veins; subsequent post-necrotic collapse and fibrosis is likely to result in cirrhosis. (05 Mar 2000) |
| p60 tumour necrosis factor receptor-associated kinase | <enzyme> Interacts with and causes phosphorylation of the cytoplasmic domain of the tnf receptor Registry number: EC 2.7.10.- Synonym: p60 tnf receptor-associated kinase, p60-trak (26 Jun 1999) |
| papillary necrosis | <radiology> Mnemonic: POST CARD, P pyelonephritis, O obstruction, S sickle cell disease, T TB, C cirrhosis (EtOH), A analgesics (phenacetin and aspirin), R renal vein thrombosis, D diabetes (12 Dec 1998) |
| receptors, tumour necrosis factor | Cell surface receptors that bind tumour necrosis factor and trigger changes which influence the behaviour of cells. The two recognised tumour necrosis factor receptors are designated alpha and beta receptors. Both receptors bind both alpha and beta tumour necrosis factors with high affinity, and both are members of the nerve growth factor receptor family. (12 Dec 1998) |
| caseous necrosis | Caseation necrosis, necrosis characteristic of certain inflammations (e.g., tuberculosis, histoplasmosis), which represents necrosis with loss of separate structures of the various cellular and histologic elements; affected tissue manifests the friable, crumbly consistency and dull, opaque quality observed in cheese. Synonym: caseous degeneration. (05 Mar 2000) |
| globus pallidus necrosis | <radiology> Carbon monoxide poisoning, barbiturate intoxication, cyanide poisoning, hydrogen sulfide poisoning, hypoglycaemia, hypoxia, hypotension, Leigh disease, Wilson disease CT: bilateral, symmetric low density in globus pallidus Cf: methanol intoxication leading to putamenal haemorrhagic necrosis (changes seen more laterally) (12 Dec 1998) |