| thiodiphenylamine | <pharmacology> A group of tranquilising medications with antipsychotic action, thought to act by blocking dopaminergic transmission in the brain. They are used to treat mental, nervous and emotional disorders. Examples include: chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, promazine, thioridazine, trifluoperazine, thiopropazate and triflupromazine. Trifluoperazine binds to and inhibits calmodulin and has been used experimentally to block calcium or calmodulin controlled reactions. (29 Sep 1997) |
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| thioester | Compounds of the type. R CO s R. See: coenzyme A, palmitoylation. (18 Nov 1997) |
| thioesterase | <enzyme> An enzyme that hydrolyzes thioesters; e.g., the deacylating activity at the end of fatty acid biosynthesis that releases palmitate. Synonym: thiolesterase. (05 Mar 2000) |
| thioesters | In enzymology, an ester where the oxygen bridging the substrate or product carbonyl carbon and the enzyme is replaced by a sulphur (usually through a cys residue); a high energy intermediate in many enzymes. (05 Mar 2000) |
| thioethanolamine acetyltransferase | <enzyme> An enzyme transferring acetyl from acetyl-CoA to the sulfur atom of thioethanolamine, thus producing coenzyme A and S-acetylthioethanolamine. Synonym: thiotransacetylase B. (05 Mar 2000) |
| thioether | The bond R s C, of which the best example is methionine. (18 Nov 1997) |
| thioflavin T | A yellow thiazole dye, C17H19N2SCl, used in histopathology as a fluorochrome for hyaline and amyloid. (05 Mar 2000) |
| thioflavine S | A methylated and sulfonated derivative of primulin; a yellowish dye used in fluorescence microscopy as a vital stain. (05 Mar 2000) |
| thioflavine T stain | <technique> A stain employed to detect amyloid, which induces specific yellow fluorescence; tissue sections are first put in alum-haematoxylin to quench nuclear fluorescence and then stained in thioflavine T. (05 Mar 2000) |
| thiofuran | <chemistry> A sulphur hydrocarbon, C4H4S, analogous to furfuran and benzene, and acting as the base of a large number of substances which closely resemble the corresponding aromatic derivatives. Origin: Thio- + phenyl + -ene. Source: Websters Dictionary (01 Mar 1998) |
| thiogalactosides | Galactosides in which the oxygen atom linking the sugar and aglycone is replaced by a sulfur atom. (12 Dec 1998) |
| thioglucosidase | <enzyme> An enzyme in mustard seed that converts thioglycosides into thiols plus sugars. Synonym: myrosinase, sinigrase, sinigrinase. (05 Mar 2000) |
| thioglycerol | Alpha-Monothioglycerol; 3-mercapto-1,2-propanediol;used to promote wound healing. Synonym: thioglycerol. (05 Mar 2000) |
| thioglycolate | Thioglycollate A salt or ester of thioglycolic acid; frequently used in bacterial media to reduce their oxygen content so as to create favourable conditions for the growth of anaerobes; the thioglycolate will also inactivate any mercurial that might be carried over with the inoculum. (05 Mar 2000) |
| thioglycolates | Organic esters of thioglycolic acid (hs-ch2cooh). (12 Dec 1998) |