| suppression, genetic | The restoration of the wild-type phenotype in an organism possessing a mutationally altered genotype. The effects of the mutation may be suppressed by a second "suppressor" mutation on a different gene, by a suppressor mutation on the same gene but located at a distance from the site of the primary mutation, or by the presence of a cytoplasmic suppressor due to a change in non-chromosomal DNA. (12 Dec 1998) |
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| suppressive | Tending to suppress: effecting suppression, specifically: serving to suppress activity, function, symptoms. (18 Nov 1997) |
| suppressor | A compound that suppresses the effects of mutation or suppresses what would be a normal course of events. (05 Mar 2000) |
| suppressor cell | <immunology> Lymphocyte class of cells suppressing T or B antigen dependent responses. (18 Nov 1997) |
| suppressor cells | Cells of the immune system that inhibit or help to terminate an immune response, e.g., suppressor macrophages and suppressor T-cells. Synonym: cytotoxic cell. (05 Mar 2000) |
| suppressor factor | <immunology> Factors released by T suppressor cells. See: suppressor mutation, ochre suppressor, opal suppressor. (19 Jan 1998) |
| suppressor factors, immunologic | Proteins, protein complexes, or glycoproteins secreted by suppressor T-cells that inhibit either subsequent T-cells, B-cells, or other immunologic phenomena. Some of these factors have both histocompatibility (I-j) and antigen-specific domains which may be linked by disulfide bridges. They can be elicited by haptens or other antigens and may be mass-produced by hybridomas or monoclones in the laboratory. (12 Dec 1998) |
| suppressor mutation | <molecular biology> Mutation that alleviates the effect of a primary mutation at a different locus. May be through almost any mechanism that can give a primary mutation, but perhaps the most interesting class are the amber and ochre supressors, where the anticodon of the tRNA is altered so that it mis reads the termination codon and inserts an amino acid, preventing premature termination of the peptide chain. (18 Nov 1997) |
| suppressor T-cell | <immunology> See T-cells. (18 Nov 1997) |
| suppressor tRNA | The tRNA associated with a suppressor mutation. (05 Mar 2000) |
| suppressor-sensitive mutant | A conditionally lethal, host range, bacteriophage mutant that produces nonsense codons and can replicate only in a host bacterium able to translate the nonsense codon; the mutation's effects are lethal (i.e., prevent replication of the virus) in a bacterium without such a suppressor mechanism. (05 Mar 2000) |
| suppurant | <medicine> A suppurative. Source: Websters Dictionary (01 Mar 1998) |
| suppurate | To form pus. Origin: L. Sup-puro (subp-), pp. -atus, to form pus (pur), pus (05 Mar 2000) |
| suppuration | <pathology> The formation of pus, the act of becoming converted into and discharging pus. Origin: L. Puris = pus (18 Nov 1997) |
| suppurative | Tending to suppurate; promoting suppuration. <medicine> Suppurative fever, pyaemia. Origin: Cf. F. Suppuratif. <medicine> A suppurative medicine. Source: Websters Dictionary (01 Mar 1998) |