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sphingomyelin phosphodiesterase [EC 3.1.4.12] an enzyme of the hydrolase class that catalyzes the cleavage of sphingomyelin to ceramide and phosphorylated choline in the major pathway for sphingomyelin degradation. Deficiency of the enzyme, an autosomal recessive trait, causes Niemann-Pick disease. Called also sphingomyelinase.
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sphingomyelinase sphingomyelin phosphodiesterase.
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sphingomyelinase d. Niemann-Pick disease.
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sphingomyelinosis Niemann-Pick disease.
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sphingophospholipid a phospholipid derived from sphingosine or a related base; in higher animals, the most abundant are the sphingomyelins.
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