| senile plaque | <neurology> Characteristic feature of the brains of Alzheimer's patients and aged monkeys, consisting of a core of amyloid fibrils surrounded by dystrophic neurites. The principal component of amyloid fibrils in senile plaques is B/A4, a peptide of about 4 kD that is derived from the larger amyloid precursor protein (APP). The B/A4 sequence is located near the C terminus of APP. (18 Nov 1997) |
|---|---|
| senile plaques | Microscopic argyrophilic masses composed of fragmented axon terminals and dendrites surrounding a core of amyloid. They are seen in small amounts in the cerebral cortex of normal elderly people and in larger amounts in those with alzheimer disease. (12 Dec 1998) |
| senile psychosis | Mental disturbance occurring in old age and related to degenerative cerebral processes. (05 Mar 2000) |
| senile retinoschisis | Retinoschisis occurring most often in the elderly and affecting the outer plexiform layer; it begins in the extreme inferotemporal periphery and is not significantly progressive; vision usually is good. (05 Mar 2000) |
| senile sebaceous hyperplasia | Hyperplasia of mature sebaceous glands, forming a nodule on the skin of the face or forehead in elderly persons. (05 Mar 2000) |
| senile tremor | An essential tremor that becomes symptomatic in elderly adults. (05 Mar 2000) |
| senile wart | <dermatology> A skin lesion that is abnormally sensitive to the effects of ultraviolet light (sunlight). Thought to be a precancerous skin lesion that is more common in the fair-skinned or elderly individual. Approximately 20% of these skin lesions will develop into squamous cell carcinoma. Prevention includes the use of sun screen agents and the avoidance of drugs (for example tetracyclines) known to cause photosensitivity reactions. Usually a discreet slightly raised, red or pink lesion located on a sun exposed surface. Texture may appear as rough, gritty or scaly. Growths may be biopsied to look for cancer or removed via cryotherapy or electrical cautery. Some topical agents may be used to promote peeling. (27 Sep 1997) |
| acute reflex bone atrophy | Atrophy of bones, commonly of the carpal or tarsal bones, following a slight injury such as a sprain. See: causalgia, reflex sympathetic dystrophy. Synonym: acute reflex bone atrophy, posttraumatic osteoporosis, Sudeck's syndrome. Origin: L. English sweat (05 Mar 2000) |
| acute yellow atrophy of the liver | A lesion in which there is extensive and rapid death of parenchymal cells of the liver, sometimes with fatty degeneration of the size of the organ; the necrosis may result from fulminant viral infection or chemical poisoning; associated with jaundice. Synonym: acute parenchymatous hepatitis, Rokitansky's disease. (05 Mar 2000) |
| alveolar atrophy | Diminution in size of the supportive tissues of the teeth due to lack of function, reduced blood supply, or unknown causes. (05 Mar 2000) |
| arthritic atrophy | Atrophy of muscles rendered inactive by a chronically inflamed or fixed joint. (05 Mar 2000) |
| atrophy | <pathology> A wasting away, a diminution in the size of a cell, tissue, organ or part. Origin: L., Gr. Atrophia (16 Dec 1997) |
| back-pressure renal atrophy | <radiology> Caliectasis without obstruction, due to repeated episodes of obstruction, gradual loss of renal pyramids (12 Dec 1998) |
| blue atrophy | Depressed blue atrophic scars due to injections in the skin of impure substances, as seen in narcotics addicts. (05 Mar 2000) |
| brown atrophy | Atrophy of the heart wall, especially in the elderly, in which the muscle is dark reddish brown and reduced in volume; the muscle fibres become pigmented especially about the nuclei, by lipochrome granules. (05 Mar 2000) |