| familial goiter | A group of heritable thyroid disorders in which goiter is commonly apparent first during childhood; often associated with skeletal and/or mental retardation, and with other signs of hypothyroidism that may develop with age. Various types of familial goiter have been identified: 1) iodide transport defect, in which the gland is unable to concentrate iodide; 2) organification defect, in which the iodination of tyrosine is defective; 3) Pendred's syndrome; 4) coupling defect, in which cretinism results from defective coupling of iodotyrosines to form iodothyronines; 5) iodotyrosine deiodinase defect, in which deiodination of iodotyrosine is defective, considerable glandular loss of these hormonal precursors occurs, and cretinism may be present; 6) plasma iodoprotein disorder, in which an abnormal iodinated serum protein that is insoluble in acidic butanol is present; 7) hereditary hyperthyroidism. (05 Mar 2000) |
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| fibrous goiter | A firm hyperplasia of the thyroid and its capsule. (05 Mar 2000) |
| follicular goiter | A form of goiter in which there is a great increase in the follicles with proliferation of the epithelium. Synonym: follicular goiter. (05 Mar 2000) |
| lingual goiter | A tumour of thyroid tissue involving the embryonic rudiment at the base of the tongue. (05 Mar 2000) |
| lymphadenoid goiter | <endocrinology> Inflammation of the thyroid gland without the formation of pus. Noninfectious nonbacterial thyroid inflammation. (27 Sep 1997) |