| multidrug resistance | The insensitivity of various tumours to a variety of chemically related anticancer drugs; mediated by a process of inactivating the drug or removing it from the target tumour cells. (05 Mar 2000) |
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| mutual resistance | An interaction between chemicals in which one partially or completelyinhibits the effect of the other (for example, a drug that blocks a hormone's receptor site would be a hormone antagonist). (09 Oct 1997) |
| cross-resistance | <immunology, microbiology> Immunologic resistance to the pathogenic effects of a microorganism because of previous exposure to another species or type having cross reactive antigens. This phenomenon is seen in microbes that acquire resistance to one drug through direct exposure and turn out to have resistance to one or more other drugs to which it has not been exposed. Cross-resistance arises because the mechanism of resistance to several drugs is the same and arises through the identical genetic mutations. (09 Oct 1997) |
| sisomicin-gentamicin resistance ribosomal RNA methylase | <enzyme> Catalyses the methylation of 30s ribosomal units to confer sisomicin-gentamicin resistance in micromonospora zionensis Registry number: EC 2.1.1.- Synonym: sgm gene product, sgm methylase (26 Jun 1999) |
| synaptic resistance | The ease or difficulty with which a nerve impulse can cross a synapse. (05 Mar 2000) |
| systemic vascular resistance | An index of arteriolar compliance or constriction throughout the body; equal to the blood pressure divided by the cardiac output. (05 Mar 2000) |
| dicumarol resistance | A well-defined autosomal dominant resistance to it, over and above general variability in tolerance to the drug. (05 Mar 2000) |
| drug resistance | The ability of bacteria and other microorganisms to withstand a drug to which they were once sensitive (and were once stalled or killed outright). (12 Dec 1998) |
| drug resistance, microbial | The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through plasmids containing resistance factors (r factors). (12 Dec 1998) |
| drug resistance, multiple | Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. (12 Dec 1998) |
| drug resistance, neoplasm | Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures. (12 Dec 1998) |
| impact resistance | The ability of a lens for eyewear to withstand impact without shattering or breaking, i.e., of a 3/8 -inch steel ball dropped 50 feet; criteria for determination of impact resistance are specified by U.S. Regulations. (05 Mar 2000) |
| inductive resistance | The weakening of an alternating electric current by passage through a coil of wire or a condenser. Synonym: inductive resistance. (05 Mar 2000) |
| insecticide resistance | The development by insects of resistance to insecticide. (12 Dec 1998) |
| insulin resistance | Many people with noninsulin-dependent diabetes produce enough insulin, but their bodies do not respond to the action of insulin. This may happen because the person is overweight and has too many fat cells, which do not respond well to insulin. Also, as people age, their body cells lose some of the ability to respond to insulin. Insulin resistance is also linked to high blood pressure and high levels of fat in the blood. Another kind of insulin resistance may happen in some people who take insulin injections. They may have to take very high doses of insulin every day (200 units or more) to bring their blood glucose (sugar) down to the normal range. (09 Oct 1997) |