| IL-8 | Interleukin-8 |
|---|---|
| ICE | ice, compression, elevation; ichthyosis-cheek-eyebrow [syndrome]; immunochemical evaluation; interle... |
| IL | ileum; incisolingual; independent laboratory; iliolumbar; independent laboratory; inspiratory load; ... |
| IL-1 | interleukin 1 |
| IL-2 | interleukin 2 |
| interleukin-13 | <cytokine> A T-lymphocyte-derived cytokine that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-lymphocytes. It appears to play a role in regulating inflammatory and immune responses and has anti-inflammatory activity. Produced by activated T-cells, inhibits IL-6 production by monocytes and also the production of other pro inflammatory cytokines such as TNF, IL-1, IL-8. Stimulates B-cells. Gene is located in cluster of genes on human chromosome 5q that also has IL-4 gene. Acronym: IL-13 (12 Dec 1998) |
|---|---|
| interleukin-14 | Cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations. Acronym: IL-14 (12 Dec 1998) |
| interleukin-15 | Cytokine that stimulates the proliferation of T-lymphocytes and shares biological activities with il-2. Il-15 also can induce b-lymphocyte proliferation and differentiation. Acronym: IL-15 (12 Dec 1998) |
| interleukin-16 | Cytokine produced by activated T-lymphocytes that stimulates the migration of CD4-positive lymphocytes and monocytes. It has been reported to suppress HIV replication. (12 Dec 1998) |
| interleukin-1 converting enzyme | <biochemistry> Cytoplasmic cysteine protease that is uniquely responsible for cleaving proIL-1_ (31 or 33 kD) into mature IL-1_ (17.5 kD), the active cytokine is then released by a nonstandard mechanism (there is no signal sequence and it does not pass through the Golgi). The enzyme seems to be composed of two nonidentical subunits derived from a single proenzyme. The ICE gene has some homology with the ced 9 gene of C. Elegans, the product of which is involved in mediating cell death by apoptosis. (11 Mar 1998) |
| interleukin-2 | <cytokine> A hormone-like substance released by stimulated T lymphocytes, causes activation and differentiation of other T lymphocytes independently of antigen. A type of interleukin, a chemical messenger, a substance that can improve the body's response to disease. It stimulates the growth of certain disease-fighting blood cells in the immune system. It is secreted by Thl CD4 cells to stimulate CD8 cytotoxic T-1yrnphocytes. Interleukin 2 also increases the proliferation and maturation of the CD4 cells themselves. During HIV infection, Interleukin-2 production gradually declines. Use of interleukin 2 therapy is under study as a way to raise CD4 cell counts and restore immune function. Acronym: IL-2 (12 Dec 1998) |
| interleukin-3 | <cytokine> Product of mitogen activated T-cells: colony-stimulating factor for bone marrow stem cells and mast cells. A multilineage cell growth factor secreted by lymphocytes, epithelial cells, and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells. It is considered one of the haematopoietic colony-stimulating factors. Synonym: multi-CSF Acronym: IL-3 (12 Dec 1998) |
| interleukin-4 | <cytokine> A soluble cytokine factor produced by activated T-lymphocytes that promotes antibody production by causing proliferation and differentiation of B-cells. Interleukin-4 induces the expression of class II major histocompatibility complex and fc receptors on B-cells. It also acts on T-lymphocytes, mast cell lines, and several other haematopoietic lineage cells including granulocyte, megakaryocyte, and erythroid precursors, as well as macrophages. Acronym: IL-4 (12 Dec 1998) |
| interleukin-5 | <cytokine> A factor promoting eosinophil differentiation and activation in haematopoiesis. It also triggers activated B-cells for a terminal differentiation into Ig-secreting cells. Acronym: IL-5 (12 Dec 1998) |
| interleukin-6 | <cytokine> A cytokine that stimulates the growth and differentiation of human B-cells and is also a growth factor for hybridomas and plasmacytomas. It is produced by many different cells including T-cells, monocytes, and fibroblasts. A single chain 25 kD cytokine originally described as a pre B-cell growth factor, now known to have effects on a number of other cells including T-cells which are also stimulated to proliferate. An inducer of acute phase proteins and a colony-stimulating factor acting on mouse bone marrow. Acronym: IL-6 (12 Dec 1998) |
| interleukin-7 | <cytokine> A haematopoietic growth factor that promotes growth of B-cell precursors and is also co-mitogenic with interleukin-2 for mature T-cell activation. It is produced by bone marrow stromal cells. Acronym: IL-7 (12 Dec 1998) |
| interleukin-8 | <cytokine> A cytokine that activates neutrophils and attracts neutrophils and T-lymphocytes. It is released by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes by an inflammatory stimulus. Il-8 is a member of the beta-thromboglobulin superfamily and structurally related to platelet factor 4. Acronym: IL-8 (12 Dec 1998) |
| interleukin-9 | <cytokine> Cytokine produced by T-cells, particularly when mitogen stimulated, that stimulates the proliferation of erythroid precursor cells (BFU E). It is thought to be a regulator of haematopoiesis and may act synergistically with erythropoietin. Receptor belongs to haemopoietic receptor super family. It has been shown to enhance the growth of human mast cells and megakaryoblastic leukaemic cells as well as murine helper T-cell clones. Il-9 is a glycoprotein with a molecular weight of 32-39 that is derived from T-cells, and maps to human chromosome 5. Acronym: IL-9 (12 Dec 1998) |
| adenoviruses, human | Species of the genus mastadenovirus, causing a wide range of diseases in humans. Infections are mostly asymptomatic, but can be associated with diseases of the respiratory, ocular, and gastrointestinal systems. (12 Dec 1998) |
| adenovirus infections, human | Respiratory and conjunctival infections caused by 33 identified serotypes of human adenoviruses. (12 Dec 1998) |