| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| 영문 | Electric convulsive therapy(ECT) | 한글 | 전기경련요법 |
|---|---|---|---|
| 설명 | 뇌에 전기 자극을 주어 인위적으로 경련을 유발함으로써 정신 병을 치료하는 방법. 전기쇼크요법(electroshock therapy)이라고도 한다. 1938년에 이탈리아의 체를레티와 비니에 의해 시작되었다. 작용기전은 확실치 않으나 뇌의 신진대사, 생화학 및 효소 등에 변화를 일으킨다는 생물학적, 생화학적 학설이 유력하다. 적응증으로 가장 효과적인 병은 우울증으로 특히 여성에서 갱년기에 호발하는 갱년기 우울증, 우울증과 조증(아주 기분이 좋은 상태가 지속되는 정신병)이 일정한 주기를 두고 반복하는 조울증에 잘 쓰이며, 80~90%에서 효과가 있다. |
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| oxygen dependent killing | One of the most important bactericidal mechanisms of mammalian phagocytes involves the production of various toxic oxygen species (hydrogen peroxide, superoxide, singlet oxygen, hydroxyl radicals) through the metabolic burst. Although anaerobic killing is possible, the oxygen dependent mechanism is crucial for normal resistance to infection and a defect in this system is usually fatal within the first decade of life (chronic granulomatous disease). See: myeloperoxidase, chemiluminescence. (18 Nov 1997) |
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| oxygen deprivation theory of narcosis | That narcotics inhibit oxidation, which causes the cell to be narcotised. (05 Mar 2000) |
| oxygen derived free radicals | An atom or atom group having an unpaired electron on an oxygen atom, typically derived from molecular oxygen. For example, one-electron reduction of O2 produces the superoxide radical, O2-; other examples include the hydroperoxyl radical (HOO-), the hydroxyl radical (HO-), and nitric oxide (NO-). (05 Mar 2000) |
| oxygen effect | Enhancement of radiosensitivity of cells in a high concentration of oxygen. (05 Mar 2000) |
| oxygen electrode | A sensitive method to detect oxygen consumption, involves a PTFE (Teflon) membrane. (18 Nov 1997) |
| oxygen isotopes | Stable oxygen atoms that have the same atomic number as the element oxygen, but differ in atomic weight. O-17 and 18 are stable oxygen isotopes. (12 Dec 1998) |
| oxygen poisoning | A body disturbance resulting from breathing high partial pressures of oxygen; characterised by visual and hearing abnormalities, unusual fatigue while breathing, muscular twitching, anxiety, confusion, incoordination, and convulsions; although the mechanism for development of the condition is obscure, a disruption of enzymatic activity is likely, perhaps as a result of free radical formation. Synonym: oxygen poisoning. (05 Mar 2000) |
| oxygen radical | <chemistry> Any oxygen species that carries an unpaired electron (except free oxygen). Examples are the hydroxyl radical and the superoxide anion. These radicals are very powerful oxidizing agents and cause structural damage to proteins and nucleic acids. They mediate the damaging effects of ionising radiation. (18 Nov 1997) |
| oxygen radioisotopes | Unstable isotopes of oxygen that decay or disintegrate emitting radiation. O atoms with atomic weights 13, 14, 15, 19, and 20 are radioactive oxygen isotopes. (12 Dec 1998) |
| oxygen tent | A transparent enclosure, suspended over the bed and enclosing the patient, used to supply a high concentration of oxygen. (05 Mar 2000) |
| oxygen toxicity | A body disturbance resulting from breathing high partial pressures of oxygen; characterised by visual and hearing abnormalities, unusual fatigue while breathing, muscular twitching, anxiety, confusion, incoordination, and convulsions; although the mechanism for development of the condition is obscure, a disruption of enzymatic activity is likely, perhaps as a result of free radical formation. Synonym: oxygen poisoning. (05 Mar 2000) |
| oxygen utilization coefficient | The extraction coefficient for oxygen in any given tissue. (05 Mar 2000) |
| lactacid oxygen debt | That part of an oxygen debt represented by the production of lactic acid by anaerobic glycolysis during exercise and, therefore, by the need to eliminate it by oxidative metabolism during recovery. (05 Mar 2000) |
| fructosyl aminocaproate-oxygen oxidoreductase | <enzyme> Catalyses conversion of amadori products to fructosamine; isolated from pseudomonas Registry number: EC 1.5.3.- Synonym: amadoriase, 1-deoxyfructosyl alkyl amino acid oxidase, fructosyl amino acid oxidase, faod enzyme (26 Jun 1999) |
| acupuncture therapy | Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. Heat or moxibustion and acupressure may be used in conjunction. (12 Dec 1998) |