| V-ONC | viral oncogene |
|---|---|
| JVP | [POMD P 49 - 52] 1) Jugular Vein Pressure 2) Jugular Venous Pulse ... |
| ACF | accessory clinical findings; acute care facility; anterior cervical fusion; area correction factor; ... |
| AF | abnormal frequency; acid-fast; adult female; afebrile; aflatoxin; albumin-free; albumose-free; aldeh... |
| FFF | degree of fineness of abrasive particles; field-flow fractionation; flicker fusion frequency |
| dominant oncogene | <genetics, molecular biology, oncology> A gene that stimulates cell proliferation and can drastically increase the risk of cancer development when present in a single copy. (09 Oct 1997) |
|---|---|
| immortalising oncogene | <molecular biology> A gene that upon transfectionenables a primary cell to grow indefinitely in culture. (09 Oct 1997) |
| oncogene | <molecular biology, oncology> Mutated and/or overexpressed version of a normal gene of animal cells (the proto-oncogene) that in a dominant fashion can release the cell from normal restraints on growth and thus alone or in concert with other changes, convert a cell into a tumour cell. (18 Nov 1997) |
| oncogene protein gp140(v-fms) | Transforming glycoprotein coded by the fms oncogene from the susan mcdonough strain of feline sarcoma virus (sm-fesv). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (csf-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms). (12 Dec 1998) |
| oncogene protein p21(ras) | Transforming protein encoded by ras oncogenes. Point mutations in the cellular ras gene (c-ras) can also result in a mutant p21 protein that can transform mammalian cells. Oncogene protein p21(ras) has been directly implicated in human neoplasms, perhaps accounting for as much as 15-20% of all human tumours. (12 Dec 1998) |
| oncogene protein p55(v-myc) | Transforming protein coded by myc oncogenes. The v-myc protein has been found in several replication-defective avian retrovirus isolates which induce a broad spectrum of malignancies. (12 Dec 1998) |
| oncogene protein p65(gag-jun) | Transforming protein coded by jun oncogenes (genes, jun). This is a gag-onc fusion protein of about 65 kD derived from avian sarcoma virus. V-jun lacks a negative regulatory domain that regulates transcription in c-jun. (12 Dec 1998) |
| oncogene protein pp60(v-src) | <chemical> Tyrosine-specific protein kinase encoded by the v-src oncogene of rous sarcoma virus. The transforming activity of pp60(v-src) depends on both the lack of a critical carboxy-terminal tyrosine phosphorylation site at position 527, and the attachment of pp60(v-src) to the plasma membrane which is accomplished by myristylation of its n-terminal glycine. Chemical name: Kinase (phosphorylating), protein pp60src (12 Dec 1998) |
| transforming oncogene | <molecular biology> A gene that upon transfection converts a previously immortalised cell to the malignant phenotype. (09 Oct 1997) |
| atrial fusion beat | A beat that occurs when the atria are activated in part by the sinus impulse and in part by an ectopic or retrograde impulse from A-V junction or ventricle. (05 Mar 2000) |
| magnetic confinement fusion | <physics> Method of fusion which uses magnetic fields / magnetic bottles to confine a hot plasma until fusion occurs. (09 Oct 1997) |
| gene fusion | Fusion of structural genes to analyze protein behaviour or fusion of regulatory sequences with structural genes to determine mechanisms of regulation. (12 Dec 1998) |
| ventricular fusion beat | A fusion beat that occurs when the ventricles are activated partly by the descending sinus or A-V junctional impulse and partly by an ectopic ventricular impulse. (05 Mar 2000) |
| vertebral fusion | A procedure that involves fusing together two or more vertebrae in the spine using either bone grafts or metal rods (Harrington rods). This procedure may be used to correct kyphosis or scoliosis. It is also used in those who require spine stabilisation due to vertebral damage from ruptures discs, fractures, osteomyelitis, osteoarthritis or tumour. (27 Sep 1997) |
| cell fusion | <biology, embryology> Fusion of two previously separate cells occurs naturally in fertilization and in the formation of vertebrate skeletal muscle, but can be induced artificially by the use of Sendai virus or fusogens such as polyethylene glycol. Fusion may be restricted to cytoplasm or nuclei may fuse as well. A cell formed by the fusion of dissimilar cells is often referred to as a heterokaryon. (26 Mar 1998) |