| immunoglobulin variable region | That region of the immunoglobulin (antibody) molecule that varies in its amino acid sequence and composition, confers the antigenic specificity, and is thought to comprise the binding site for the antigen. It is located at the n-terminus of the fab fragment of the immunoglobulin. It includes hypervariable and framework regions, vh family subgroups, and the complementarity-determining region. (12 Dec 1998) |
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| independent variable | A characteristic being measured or observed that is hypothesised to influence another event or manifestation (the dependent variable) within a defined area of relationships under study; that is, the independent variable is not influenced by the event or manifestation, but may cause it or contribute to its variation. See: dependent variable. (05 Mar 2000) |
| intermediate variable | A variable in a causal pathway that causes variation in the dependent variable and is itself caused to vary by the independent variable. (05 Mar 2000) |
| intervening variable | An event, such as an attitude or emotion, inferred to occur within an organism between the stimulation and response in such a way as to influence or determine the response. (05 Mar 2000) |
| ordered on-random off mechanism | A scheme for substrate binding and product release for multisubstrate enzymes; for a two-substrate two-product enzyme with this mechanism, the individuals have to bind to the enzyme in a distinct order; however, once the products are formed they may dissociate from the enzyme in either order. It has been suggested that pyruvate kinase has such a mechanism. The random on-ordered off mechanism is simply the reverse of this mechanism. (05 Mar 2000) |
| malignant mixed mullerian tumour | A sarcoma of the body of the uterus arising in older women, composed of more than one mesenchymal tissue, especially including striated muscle cells. Synonym: malignant mixed mullerian tumour. (05 Mar 2000) |
| gonadal dysgenesis, mixed | A syndrome of gonadal dysgenesis in which there is a testis on one side and a "streak gonad" on the other. The phenotype is generally male, but may be female since the individual is a mosaic. Various karyotypes have been identified, including 45,xo/47,xyy; 45,xo/46,xy; and 45,xo/46,xyo. (12 Dec 1998) |
| mixed | Formed by mixing; united; mingled; blended. See Mix, Mixed action, voices of both males and females united in the same performance. Source: Websters Dictionary (01 Mar 1998) |
| mixed agglutination | Immune agglutination in which the aggregates contain cells of two different kinds but with common antigenic determinants; when used to identify isoantigens, the test cells are exposed to appropriate isoantibody, washed, and then mixed with indicator erythrocytes that combine with free sites on the test cell-attached isoantibody. Synonym: mixed agglutination. (05 Mar 2000) |
| mixed agglutination reaction | Immune agglutination in which the aggregates contain cells of two different kinds but with common antigenic determinants; when used to identify isoantigens, the test cells are exposed to appropriate isoantibody, washed, and then mixed with indicator erythrocytes that combine with free sites on the test cell-attached isoantibody. Synonym: mixed agglutination. (05 Mar 2000) |
| mixed aphasia | In which all aspects of speech and communication are severely impaired. at best, patients can understand or speak only a few words or phrases; they cannot read or write. Synonym: mixed aphasia, total aphasia. (05 Mar 2000) |
| mixed astigmatism | Astigmatism in which one meridian is hyperopic while the one at right angle to it is myopic. (05 Mar 2000) |
| mixed beat | A beat triggered by more than a single electrical impulse, when the wave fronts coincide to act together on a single final pathway of activity; in the electrocardiogram, the atrial or ventricular complex when either atria or ventricles are activated jointly by two simultaneous or nearly simultaneous invading impulses. Synonym: combination beat, mixed beat, summation beat. (05 Mar 2000) |
| mixed cell leukaemia | Term infrequently used as a designation for granulocytic leukaemia, thereby emphasizing the occurrence of different types of cells in the myeloid series (i.e., neutrophilic, eosinophilic, and basophilic granulocytes), in contrast to the comparatively monotonous pattern observed in lymphocytic and monocytic leukaemia. (05 Mar 2000) |
| mixed chancre | A sore resulting from simultaneous inoculation of a site with syphilis and chancroid. (05 Mar 2000) |