| lobular glomerulonephritis | <pathology> A kidney disorder which results in kidney dysfunction. Inflammation of the glomeruli result from an abnormal immune response and the deposition of antibodies within the kidney (glomerulus) ultrastructure. Membranoproliferative glomerulonephritis has been divided into two different types in the basis of where the antibodies are deposited in the glomerulus. MPGN type I, the more common type, deposits antibodies in the subendothelial layer of the basement membrane, whereas type II deposits antibodies in the bottom layer of the basement membrane. Symptoms include cloudy urine (pyuria), decreased urine output, swelling and hypertension. This disorder often results in end-stage renal disease. Acronym: MPGN (26 Mar 1998) |
|---|---|
| local glomerulonephritis | Glomerulonephritis affecting only part of a glomerulus or glomeruli. Synonym: local glomerulonephritis. (05 Mar 2000) |
| lupus glomerulonephritis-pathology | Patient survival and preservation of renal function are predictable from renal pathology as demonstrated by biopsy and defined by the histological classification of the International Study of Kidney Disease in Children/World Health Organization (ISKDC/WHO). Semi-quantitative indices of nephron loss (chronicity index) and activity of acute potentially reversible inflammation (activity index) are not predictive of individual outcome, renal failure or death in patients with aggressively treated SLE GN. (05 Mar 2000) |
| cancer, malignant melanoma | A skin cancer that begins in cells called melanocytes that can grow together to form benign (not cancerous) moles. A change in size, shape, or colour of a mole can be a sign of melanoma. Melanoma can be cured if detected early, before spread (metastasis) to other areas of the body. Diagnosis is confirmed with a biopsy of the abnormal skin. Sun exposure can cause skin damage that can lead to melanoma. (12 Dec 1998) |
| canine malignant lymphoma | <tumour> A progressive fatal disease of dogs characterised by neoplastic transformation and proliferation of lymphoid cells, usually originating in solid lymphoid organs (lymphosarcoma) or bone marrow (lymphocytic leukaemia). (05 Mar 2000) |
| malignant | <oncology> Tending to become progressively worse and to result in death. Having the properties of anaplasia, invasion and metastasis, said of tumours. Origin: L. Malignans = acting maliciously (18 Nov 1997) |
| malignant anaemia | <haematology> A form of anaemia (low red blood cell counts) that results when the bone marrow fails to produce adequate numbers of red blood cells due to a deficiency in vitamin B12. Intrinsic factor, necessary for normal B12 absorption, may be the underlying cause for B12 deficiency if is not produced in the gastric glands (in the stomach). Origin: Gr. Haima = blood (27 Sep 1997) |
| malignant carcinoid syndrome | <syndrome> A symptom complex associated with carcinoid tumour and characterised by attacks of severe flushing of the skin, diarrhoeal watery stools, bronchoconstriction, sudden drops in blood pressure, oedema, and ascites. The carcinoid tumours are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumour secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute carcinoid heart disease. (12 Dec 1998) |
| malignant catarrh | A herpes virus infection of cattle characterised by catarrhal inflammation of the upper respiratory and alimentary epithelia, keratoconjunctivitis, encephalitis and lymph node enlargement. Syn: bovine epitheliosis, snotsiekte. (12 Dec 1998) |
| malignant catarrhal fever | A highly fatal, sporadic disease of cattle caused by alcelaphine herpesvirus 1 (a member of the Herpesviridae family) and characterised by inflammation, ulceration, and exudation of the oral and upper respiratory mucous membranes, and sometimes eye lesions and nervous system disturbances. Synonym: malignant catarrh of cattle. (05 Mar 2000) |
| malignant catarrhal fever virus | A herpesvirus of wide distribution causing malignant catarrhal fever of cattle; sheep and wildebeests harbor inapparent infections and may transmit the virus to cattle. (05 Mar 2000) |
| malignant catarrh of cattle | A highly fatal, sporadic disease of cattle caused by alcelaphine herpesvirus 1 (a member of the Herpesviridae family) and characterised by inflammation, ulceration, and exudation of the oral and upper respiratory mucous membranes, and sometimes eye lesions and nervous system disturbances. Synonym: malignant catarrh of cattle. (05 Mar 2000) |
| malignant ciliary epithelioma | <tumour> Malignant hyperplasia of ciliary epithelium with frequent involvement of the pigmented layer. Synonym: adult medulloepithelioma. (05 Mar 2000) |
| malignant dysentery | Dysentery in which the symptoms are intensely acute, leading to prostration, collapse, and often death. Synonym: fulminating dysentery. (05 Mar 2000) |
| malignant dyskeratosis | Dyskeratosis that may occur in precancerous or malignant lesions. (05 Mar 2000) |