| malignant granuloma | Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases. An obsolete term for polymorphic reticulosis. Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma. (05 Mar 2000) |
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| malignant hepatoma | <tumour> A carcinoma derived from parenchymal cells of the liver. Synonym: hepatocarcinoma, hepatocellular carcinoma, liver cell carcinoma. (05 Mar 2000) |
| malignant histiocytosis | A rapidly fatal form of lymphoma, characterised by fever, jaundice, pancytopenia, and enlargement of the liver, spleen, and lymph nodes; the affected organs show focal necrosis and haemorrhage, with proliferation of histiocytes and phagocytosis of red blood cells. (05 Mar 2000) |
| malignant hyperphenylalaninaemia | DHPR-deficient form; an inherited disorder in which there is an absence or deficiency of dihydropteridine reductase (DHPR); this results in impaired regeneration of tetrahydrobiopterin, causing an elevation in phenylalanine levels, GTP-CH form; an inherited disorder in which there is a deficiency of guanosine triphosphate cyclohydrolase, an enzyme used in the biosynthesis of tetrahydrobiopterin, 6-PTS form; an inherited disorder in which there is a deficiency of 6-pyruvoyl tetrahydropterin synthase, an enzyme that participates in the biosynthesis of tetrahydrobiopterin. Synonym: nonclassical phenylketonuria. (05 Mar 2000) |
| malignant hyperpyrexia | A severe and often fatal illness produced by exposure to excessively high temperatures, especially when accompanied by marked exertion. It can manifest by elevated body temperature, lack of sweating, hot dry skin, and neurologic symptoms; unconsciousness, paralysis, headache, vertigo, confusion. In severe cases very high fever, vascular collapse, and coma develop. Synonym: heat apoplexy, heat hyperpyrexia, malignant hyperpyrexia, thermic fever. (05 Mar 2000) |
| malignant hypertension | A severe form of acute hypertension that results in the abrupt rise in the blood pressure (diastolic pressure often over 120 mmHg). If left untreated, malignant hypertension can cause damage to the blood vessels in the eye, kidneys, brain and heart. Complications include stroke, heart attack, blindness and renal failure. Symptoms include headache, blurred vision, nausea, vomiting and lethargy. Neurologic symptoms are also a common finding. Malignant hypertension occurs more commonly in males, African Americans and those with a history for hypertension. (27 Sep 1997) |
| malignant hyperthermia | A severe form of fever that occurs as a reaction to certain anaesthetic agents and muscle relaxants. Malignant hyperthermia is an inherited autosomal dominant condition. Inheritance: autosomal dominant. (27 Sep 1997) |
| malignant jaundice | Jaundice associated with high fever and delirium; seen in severe hepatitis and other diseases of the liver with severe functional failure. Synonym: malignant jaundice. (05 Mar 2000) |
| malignant lentigo melanoma | <tumour> A melanoma arising from a malignant lentigo. (05 Mar 2000) |
| malignant liver tumours | <radiology> EPITHELIAL TUMORS, hepatocellular, hepatoblastoma (7%), hepatocellular carcinoma (HCC) (75%), cholangiocellular (6%), cholangiocarcinomarcinoma, cystadenocarcinoma, MESENCHYMAL TUMORS, tumours of blood vessels, angiosarcoma, haemangioendothelioma, other tumours, embryonal sarcoma, fibrosarcoma, TUMORS OF MUSCLE TISSUE, leiomyosarcoma, rhabdomyosarcoma, MISCELLANEOUS, carcinosarcoma, teratoma, yolk sac tumour, carcinoid, squamous carcinoma, primary lymphoma see: benign liver tumours (12 Dec 1998) |
| malignant lymphadenosis | An obsolete term for malignant lymphoma. (05 Mar 2000) |
| malignant lymphoma | <tumour> A general term for ordinarily malignant neoplasms of lymphoid and reticuloendothelial tissues which present as apparently circumscribed solid tumours composed of cells that appear primitive or resemble lymphocytes, plasma cells, or histiocytes. Lymphomas appear most frequently in lymph nodes, spleen, or other normal sites of lymphoreticular cells; when disseminated, Lymphoma's, especially of the lymphocytic type, may invade the peripheral blood and manifest as leukaemia. Lymphomas are classified by cell type, degrees of differentiation, and nodular or diffuse pattern; Hodgkin's disease and Burkitt's lymphoma are special forms. (05 Mar 2000) |
| malignant malnutrition | A nutritional deficiency illness in children who are not getting enough protein, this results in anaemia, poor growth, weakness, and oedema (which isparticularly characterised by a pronounced pot belly). Infamine-stricken regions, children typically develop kwashiorkor rightafter they are weaned. (09 Oct 1997) |
| malignant melanoma | <oncology, tumour> A malignant tumour which arises from the pigment producing cells (melanosomes) of the deeper layers of the skin (or the eye). Melanoma is the leading cause of death attributable to skin lesions. Described as an irregular dark skin lesion that may have areas of varying colour. Often greater than 6 mm in diameter. (27 Sep 1997) |
| malignant melanoma: gallium imaging | <radiology> Greater than50% sensitivity for primary and metastatic sites: 73% sensitivity if lesion is greater than 2 cm, 17% sensitivity if less than 2 cm, see: gallium: indications malignant melanoma (12 Dec 1998) |