| DF | decapacitation factor; decontamination factor; deferoxamine; deficiency factor; defined flora [anima... |
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| GRF | gastrin-releasing factor; genetically related macrophage factor; gonadotropin-releasing factor; grow... |
| HSF | heat shock factor; hepatocyte stimulatory factor; histamine sensitizing factor; human serum esterase... |
| LPF | leukocytosis-promoting factor; leukopenia factor; lipopolysaccharide factor; localized plaque format... |
| MRF | Markov random field; medical record file; melanocyte-[stimulating hormone]-releasing factor; mesence... |
| minor lymphocyte stimulatory antigens | Endogenous superantigens responsible for inducing strong proliferative responses in T-cells in mixed lymphocyte reactions (see mixed lymphocyte culture test). They are encoded by mouse mammary tumour viruses that have integrated into the germ line as DNA proviruses (minor lymphocyte stimulatory loci). (12 Dec 1998) |
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| minor lymphocyte stimulatory loci | Genetic loci responsible for the encoding of minor lymphocyte stimulatory antigens. There are at least two unlinked loci (in the mouse) and they appear to be separate from the major histocompatibility complex and minor histocompatibility loci. The mouse mammary tumour virus (see mammary tumour viruses, mouse) has the ability to integrate into these loci. The antigens induce strong T-cell proliferative responses in mixed lymphocyte reactions. (12 Dec 1998) |
| mixed lymphocyte culture | <investigation> Test to determine whether a patients and donor's white blood cells interact adversely. Often used to determine whether a person would be a suitable bone marrow donor for a particular patient. (16 Dec 1997) |
| mixed lymphocyte culture test | Measure of histocompatibility at the hl-a locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way mlc test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin c or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens. (12 Dec 1998) |
| mixed lymphocyte reaction | <haematology, immunology, investigation> Reaction of mitogenesis produced in T lymphocytes when allogeneic (i.e. Mixed) lymphocytes are brought together, provided they are mismatched in histocompatibility loci. Once used as a test for possible graft compatibility in human grafting. Now known that a negative reaction is a poor predictor of graft acceptance. (18 Nov 1997) |
| pre-B lymphocyte | An early B-lymphoid type cell that is recognised by immunofluorescence as a u-positive, L-chain-negative bone marrow cell. (05 Mar 2000) |
| cytotoxic t-lymphocyte | A type of CD8 or, less often, CD4 lymphocyte that kills diseased cells infected by a specific virus or other intracellular microbe. CTLs interact with MHC class I receptors (see Major Histocompatibility Complex). On infected cells and have the prime role in cellmediated immunity (see). Cytovene: See: Ganciclovir. (09 Oct 1997) |
| cytotoxic T lymphocyte-specific serine protease | <enzyme> Structural sequence given in first source Registry number: EC 3.4.21.- Synonym: cytotoxic t lymphocyte-specific serine protease ccp I, cytotoxic t lymphocyte specific serine protease ccp II, mast cell protease type II (26 Jun 1999) |
| helper t lymphocyte | <haematology, immunology> A type of white blood cell produced by the thymus gland whose presence is necessary for normal levels of antibodies to be produced by B lymphocytes, both in the body (in vivo) and in experimental situations (in vitro). (09 Oct 1997) |
| human lymphocyte antigen | A system designation for the gene products of at least four linked loci (A, B, C, and D) and a member of subloci on the sixth human chromosome which have been shown to have a strong influence on human allotransplantation, transfusions in refractory patients, and certain disease associations; more than 50 alleles are recognised, most of which are at loci HLA-A and HLA-B; autosomal dominant inheritance. (05 Mar 2000) |
| subacute lymphocyte thyroiditis | A subacute variant of Hashimoto's thyroiditis. (05 Mar 2000) |
| t4 helper lymphocyte | A specific type of lymphocyte, derived from the thymus gland, that plays an important role in cellular immunity. T4 lymphocytes (CD4 cells) are decreased (absolute counts less than 200) in patients with AIDS resulting in compromised immune function. (27 Sep 1997) |
| thymus derived lymphocyte | <haematology, immunology> A class of lymphocytes, so called because they are derived from the thymus and have been through thymic processing. Involved primarily in controlling cell-mediated immune reactions and in the control of B-cell development. The T-cells coordinate the immune system by secreting lymphokine hormones. There are 3 fundamentally different types of t cells : helper, killer, and suppressor. Each has many subdivisions. T-cells are also called t lymphocytes. They bear T-cell antigen receptors (CD3) and lack Fc or C3b receptors. Major T-cell subsets are CD4 (mainly helper cells) and CD8 (mostly cytotoxic or suppressor T-cells). Uncontrolled proliferation of this type of cell gives rise to T-cell leukaemia/lymphoma. (21 Jun 1999) |
| T lymphocyte | <haematology, immunology> A class of lymphocytes, so called because they are derived from the thymus and have been through thymic processing. Involved primarily in controlling cell-mediated immune reactions and in the control of B-cell development, aiding B lymphocytes in making antibodies, and helping in the recognition and rejection of foreign tissues. T lymphocytes are also important in the bodys defense against cancer. They bear T-cell antigen receptors (CD3) and lack Fc or C3b receptors. Major T-cell subsets are CD4 (mainly helper cells) and CD8 (mostly cytotoxic or suppressor T-cells). Uncontrolled proliferation of this type of cell gives rise to T-cell leukaemia/lymphoma. (13 Nov 1997) |
| t-lymphocyte | A white blood cell made in the thymus gland, a lymphoid structure in the upper chest. T lymphocytes are also called T-cells. (the t in T-cell stands for thymus). These cells coordinate the immune system by secreting lymphokine hormones. There are 3 fundamentally different types of t lymphocytes : helper, killer, and suppressor. (12 Dec 1998) |