| LEF | leukokinesis-enhancing factor; lupus erythematosus factor; lymphoid-enhanced binding factor |
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| LES | Lambert-Eaton syndrome; Lawrence Experimental Station [agar]; local excitatory state; Locke egg seru... |
| NLE | neonatal lupus erythematosus |
| SCLE | subacute cutaneous lupus erythematosus |
| SLAM | scanning laser acoustic microscope; systemic lupus erythematosus activity measure |
| musculus flexor digitorum profundus | <anatomy, muscle> Origin, anterior surface of upper third of ulna; insertion, by four tendons, piercing those of the superficialis, into base of distal phalanx of each finger; action, flexes distal interphalangeal joint of fingers; nerve supply, ulnar and median (anterior interosseous muscle). Synonym: musculus flexor digitorum profundus, deep flexor muscle of fingers, musculus flexor profundus. (05 Mar 2000) |
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| musculus flexor profundus | <anatomy, muscle> Origin, anterior surface of upper third of ulna; insertion, by four tendons, piercing those of the superficialis, into base of distal phalanx of each finger; action, flexes distal interphalangeal joint of fingers; nerve supply, ulnar and median (anterior interosseous muscle). Synonym: musculus flexor digitorum profundus, deep flexor muscle of fingers, musculus flexor profundus. (05 Mar 2000) |
| musculus transversus perinei profundus | <anatomy, muscle> Origin, ramus of ischium; insertion, with its fellow in a median raphe; action, assists sphincter urethrae with some sphincteric action on vagina in female; nerve supply, pudendal (dorsal nerve of penis/clitoris). Synonym: musculus transversus perinei profundus, deep transverse muscle of perineum, musculus sphincter vaginae, sphincter vaginae. (05 Mar 2000) |
| profundus | Situated at a deeper level in relation to a specific reference point. Compare: superficialis. Synonym: deep. Origin: L. (05 Mar 2000) |
| nervus fibularis profundus | <anatomy, nerve> One of the terminal branches of the common peroneal nerve, arising at the fibular neck and passing into the anterior compartment of the leg; it supplies the tibialis anterior, extensor hallucis longus, extensor digitorum longus, and peroneus tertius muscles in the leg, then crosses the ankle joint to supply the muscles on the dorsum of the foot (extensors hallucis and digitorum brevis) becoming cutaneous to innervate adjacent sides of the great and second toes. Synonym: nervus fibularis profundus, nervus peroneus profundus, anterior tibial nerve, deep fibular nerve. (05 Mar 2000) |
| nervus peroneus profundus | <anatomy, nerve> One of the terminal branches of the common peroneal nerve, arising at the fibular neck and passing into the anterior compartment of the leg; it supplies the tibialis anterior, extensor hallucis longus, extensor digitorum longus, and peroneus tertius muscles in the leg, then crosses the ankle joint to supply the muscles on the dorsum of the foot (extensors hallucis and digitorum brevis) becoming cutaneous to innervate adjacent sides of the great and second toes. Synonym: nervus fibularis profundus, nervus peroneus profundus, anterior tibial nerve, deep fibular nerve. (05 Mar 2000) |
| nervus petrosus profundus | <anatomy, nerve> The deep petrosal branch of the internal carotid plexus, which joins the greater petrosal nerve at the entrance of the pterygoid canal to provide postsynaptic fibres to nerve of the pterygoid canal. Synonym: nervus petrosus profundus. (05 Mar 2000) |
| flexor digitorum profundus | <anatomy, muscle> Origin, anterior surface of upper third of ulna; insertion, by four tendons, piercing those of the superficialis, into base of distal phalanx of each finger; action, flexes distal interphalangeal joint of fingers; nerve supply, ulnar and median (anterior interosseous muscle). Synonym: musculus flexor digitorum profundus, deep flexor muscle of fingers, musculus flexor profundus. (05 Mar 2000) |
| chilblain lupus | Skin lesions seen in patients with lupus erythematosus, resembling the small, hardened nodular areas of a cold injury called chilblains. Synonym: chilblain lupus. (05 Mar 2000) |
| neonatal lupus | Lupus erythematosus occurring in newborn children of mothers who had lupus during pregnancy; anti-SSA antibodies usually should be screened for; 50% have anti-nuclear antibodies. A variety of skin lesions are seen, which can resolve or leave scarring; the syndrome usually resolves; however cardiac manifestations can be fatal. Some children develop systemic lupus later in life. (05 Mar 2000) |
| drug-induced lupus | <dermatology> An inflammatory autoimmune disorder, similar to lupus, that develops in response to the use of a particular medication. It is characterised by anti-histone antibodies. More benign than the usual disease, with less renal involvement. The syndrome clears after stopping the offending drug. Drugs that are known to cause this reaction include procainamide, isoniazid, sulphasalazine, hydralazine, methyldopa, phenytoin, chlorpromazine and penicillamine. The arthritis, cardiac, pulmonary and systemic features may be present, but the kidney involvement (nephritis) and neurologic disease are rare. Symptoms generally resolve spontaneously after stopping the medication. Complications include myocarditis, pericarditis, thrombocytopenic purpura and infections. (18 Jul 2002) |
| lupus | A systemic disease that results from an autoimmune mechanism. Individuals with lupus will produce antibodies to their own body tissues. The resultant inflammation can cause kidney damage, arthritis, pericarditis and vasculitis. (27 Sep 1997) |
| lupus anticoagulant | An immunoglobulin that interferes with blood coagulation and has antithromboplastin activity. This immunoglobulin can prolong blood clotting and occurs in approximately 25% of people with lupus. (27 Sep 1997) |
| lupus anticoagulants | Lupus anticoagulants are a common cause of a prolonged activated partial thromboplastin time (APTT) which is corrected by the addition of platelet -rich plasma (or phospholipids) and not by platelet-poor plasma. The methods of choice for detection of lupus anticoagulants are the kaolin clotting time using the rabbit brain neutralisation procedure and the dilute Russell viper venom test (dRVVT). Current data suggest that lupus anticoagulants and antibodies to negatively charged phospholipids (cardiolipin, phosphatidylserine, phosphatidic acid and phosphatidylinositol) are risk factors for arterial and venous thrombosis and for recurrent abortions in populations of patients which are distinct but overlapping. Drug-induced lupus anticoagulants are also associated with increased risk of thrombosis. Current testing for lupus anticoagulants and phospholipid antibodies (cardiolipin plus phosphatidylserine) may be useful for assessing risk in patients with systemic lupus erythematosus. Some data indicate that lupus anticoagulants assays are more reliable predictors of thrombosis, foetal loss and thrombocytopenia than are cardiolipin antibody (ACA) assays. Although the technology is in many ways more reliable, the rush to describe associations of lupus anticoagulants with various disorders has been much less scientifically unseemly than has been that of ACAs with their bewildering variety of clinical associations. The contribution of one serious study must, it seems, render tolerable the excess of trivia recently published in this area. See also cardiolipin antibodies and phospholipid antibodies. (05 Mar 2000) |
| lupus band test | A direct immunofluorescent technique for demonstrating a band of immunoglobulins at the dermal-epidermal junction of the skin of patients with lupus erythematosus. (05 Mar 2000) |