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zygotic lethal gene <genetics> A mutated or otherwise defective gene at embryonic or larval stages.
(06 May 1997)
lethal Deadly, fatal.
Origin: L. Lethalis, from lethum = death
(18 Nov 1997)
lethal coefficient <microbiology> That concentration of disinfectant that kills bacteria at 20-25°C in the shortest period of time.
(05 Mar 2000)
lethal dose <pharmacology> The amount, or dosage, of a toxin necessary to cause death.
(16 Mar 1998)
lethal dose 50 <pharmacology> The amount, or dosage, of a toxin necessary to kill 50% of the experimental subjects.
(16 Mar 1998)
lethal dwarfism Dwarfism leading to intrauterine or neonatal death.
(05 Mar 2000)
lethal factor A disorder that prevents effective reproduction by those affected; e.g., Klinefelter syndrome.
(05 Mar 2000)
lethal gene A gene that produces a genotype that leads to death of the organism before reproduction is possible or that precludes reproduction; for a recessive gene the homozygous or hemizygous state is lethal.
(05 Mar 2000)
lethal midline granuloma Destruction of the nasal septum, hard palate, lateral nasal walls, paranasal sinuses, skin of the face, orbit and nasopharynx by an inflammatory infiltrate with atypical lymphocytic and histiocytic cells; presumably a form of lymphoma in most cases.
An obsolete term for polymorphic reticulosis.
Synonym: granuloma gangrenescens, malignant granuloma, midline malignant reticulosis granuloma.
(05 Mar 2000)
lethal mutation <genetics, molecular biology> Mutation that eventually results in the death of an organism carrying the mutation.
(18 Nov 1997)
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