| glutamate decarboxylase | <enzyme> A pyridoxal-phosphate protein that catalyses the alpha-decarboxylation of l-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining gaba levels in normal nervous tissues. The brain enzyme also acts on l-cysteate, l-cysteine sulfinate, and l-aspartate. Chemical name: L-Glutamate-1-carboxy-lyase Registry number: EC 4.1.1.15 (12 Dec 1998) |
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| methionine decarboxylase | <enzyme> From fern dryopteris filix-mas; pyridoxal 5'-phosphate required for activity; converts methionine to 3-(methylthio)propionaldehyde Registry number: EC 4.1.1.57 Synonym: l-methionine decarboxylase (26 Jun 1999) |
| histidine decarboxylase | <enzyme> An enzyme that catalyses the decarboxylation of histidine to histamine and carbon dioxide. It requires pyridoxal phosphate in animal tissues, but not in microorganisms. Chemical name: L-Histidine carboxy-lyase Registry number: EC 4.1.1.22 (12 Dec 1998) |
| pyrophosphomevalonate decarboxylase | <enzyme> Chemical name: mevalonate-5-pyrophosphate decarboxylase Registry number: EC 4.1.1.33 Synonym: mevpp decarboxylase, mevalonate pyrophosphate decarboxylase, diphosphomevalonate decarboxylase (26 Jun 1999) |
| pyruvate decarboxylase | <enzyme> Catalyses the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. Registry number: EC 4.1.1.1 (12 Dec 1998) |
| hydroxypyruvate decarboxylase | <enzyme> Catalyses the nonoxidative decarboxylation of hydroxypyruvate to glycolaldehyde and co2; present in a variety of tissues in a number of species Registry number: EC 4.1.1.40 Synonym: hydroxypyruvate carboxy-lyase (26 Jun 1999) |
| hydroxytryptophan decarboxylase | <enzyme> An enzyme that catalyses the decarboxylation of l-dopa to dopamine, of l-tryptophan to tryptamine, and of l-hydroxytryptophan to serotonin; important in the biosynthetic pathway of catecholamines and melanin. Synonym: dopa decarboxylase, hydroxytryptophan decarboxylase, tryptophan decarboxylase. (05 Mar 2000) |
| sulfoalanine decarboxylase | <enzyme> Cysteine-sulfinate decarboxylase II is an aspect of glutamate decarboxylase Registry number: EC 4.1.1.29 Synonym: cysteine sulfinate decarboxylase, csa decarboxylase, cysteine sulfinic acid decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, cysteine sulphinate decarboxylase, cysteine-sulfinate decarboxylase i (26 Jun 1999) |
| decarboxylase | Any enzyme (EC subclass 4.1.1) that removes a molecule of carbon dioxide from a carboxylic group (e.g., from an alpha-amino acid, converting it into an amine). (05 Mar 2000) |
| dopa decarboxylase | <enzyme> One of the aromatic-l-amino-acid decarboxylases, this enzyme is responsible for the conversion of dopa to dopamine. It is of clinical importance in the treatment of parkinson's disease. Registry number: EC 4.1.1.- (12 Dec 1998) |
| indolepyruvate decarboxylase | <enzyme> From enterobacter cloacae; catalyses the conversion of indole-3-pyruvic acid to indole-3-acetaldehyde Registry number: EC 4.1.1- Synonym: ipdcase (26 Jun 1999) |
| OMP decarboxylase | <enzyme> An enzyme that catalyses the conversion of OMP to UMP and CO2; a defect or inhibition of this enzyme will result in orotic aciduria and orotidinuria; this enzyme is a part of pyrimidine biosynthesis. Compare: uridylic acid synthase. Synonym: OMP decarboxylase. (05 Mar 2000) |
| ornithine decarboxylase | <enzyme> The enzyme that converts ornithine to putrescine (dibasic amine) by decarboxylation. Rate limiting in the synthesis of the polyamines spermidime and spermine that regulate DNA synthesis. (18 Nov 1997) |
| orotidine-5'-phosphate decarboxylase | <enzyme> Orotidine-5'-phosphate carboxy-lyase. Catalyses the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. Chemical name: Orotidine-5'-phosphate carboxy-lyase Registry number: EC 4.1.1.23 (12 Dec 1998) |
| oxalyl CoA decarboxylase | <enzyme> Catalyses the thiamine ppi-dependent decarboxylation of oxalyl-CoA to formate and carbon dioxide Registry number: EC 4.1.1.8 Synonym: oxalyl coenzyme a decarboxylase (26 Jun 1999) |