| drug-induced disease | <pharmacology> A toxic reaction to or morbid condition resulting from the administration of a drug. (05 Mar 2000) |
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| drug-induced eosinophilic lung disease | <radiology> Diffuse reticular pattern: nitrofurantoin, Loeffler-like pattern: penicillin, sulfonamides, ASA, para-ASA, imipramine, HCTZ, cromolyn sodium see: eosinophilic lung disease (12 Dec 1998) |
| drug-induced hepatitis | <hepatology, pathology> Inflammation and hepatocellular damage of the liver that is caused by a drug. Some medications may cause inflammation of the liver as a drug side effect or drug toxicity. Drugs that are known to cause hepatitis include acetaminophen, isoniazid, halothane, methyldopa, erythromycin and oral contraceptives. (27 Sep 1997) |
| drug-induced lupus | <dermatology> An inflammatory autoimmune disorder, similar to lupus, that develops in response to the use of a particular medication. It is characterised by anti-histone antibodies. More benign than the usual disease, with less renal involvement. The syndrome clears after stopping the offending drug. Drugs that are known to cause this reaction include procainamide, isoniazid, sulphasalazine, hydralazine, methyldopa, phenytoin, chlorpromazine and penicillamine. The arthritis, cardiac, pulmonary and systemic features may be present, but the kidney involvement (nephritis) and neurologic disease are rare. Symptoms generally resolve spontaneously after stopping the medication. Complications include myocarditis, pericarditis, thrombocytopenic purpura and infections. (18 Jul 2002) |
| drug-induced tremor | <neurology, pharmacology> A drug-induced condition where there is shaking (tremor) of the extremities that is increased with purposeful movement. Drugs known to induce tremor include: theophylline, Alupent, cyclosporine, amphetamines, lithium and caffeine. (27 Sep 1997) |
| dyskinesia, drug-induced | Abnormal movements induced as an adverse reaction of drug therapy. One particular movement disorder is the "on-off" effect. Tardive dyskinesia differs from akathisia, drug-induced in the repetitive nature of the movements rather than being associated with anxiety, restlessness, and agitation found in akathisia. (12 Dec 1998) |
| induced abortion | An abortion brought on purposefully by drugs or mechanical means. (05 Mar 2000) |
| induced apnea | Intentional respiratory arrest during general anaesthesia produced by hypocapnia, a muscle relaxant drug, respiratory centre depression, or sudden cessation of controlled respiration. (05 Mar 2000) |
| induced enzyme | Inducible enzyme, an enzyme that can be detected in a growing culture of a microorganism, after the addition of a particular substance (inducer) to the culture medium, but was not detectable prior to the addition and can act on the inducer. A prototype is the beta-galactosidase of Escherichia coli, synthesised upon the addition of various galactosides, whether or not these are good substrates. Compare: constitutive enzyme. Synonym: adaptive enzyme. (05 Mar 2000) |
| induced fit | A change in the conformation of an enzyme due to it binding to asubstrate that makes it catalyticallyactive. A situation where any molecule changes shape as it binds toa ligand so that its bindingsite more closely conforms to the shape of the ligand. (09 Oct 1997) |
| induced fit model | A model to suggest a mode of action of enzymes in which the substrate binds to the active site of the protein, causing a conformational change in the protein. Synonym: Koshland-Nemethy-Filmer model. (05 Mar 2000) |
| induced labour | <obstetrics> Labour that is brought about by artificial means. (12 Dec 1998) |
| induced mutation | A mutation caused by exposure to a mutagen. (05 Mar 2000) |
| induced phagocytosis | <cell biology> Phagocytosis occurring when bacteria subjected to the action of blood serum are brought in contact with leukocytes. (05 Mar 2000) |
| induced psychotic disorder | <psychiatry> A severe mental disorder brought about by a toxic agent such as a drug or hallucinogen. See: psychosis. (05 Mar 2000) |