| CIg | intracytoplasmic immunoglobulin |
|---|---|
| cIgM | cytoplasmic immunoglobulin M |
| CIT | citrate; combined intermittent therapy; conjugated-immunoglobulin technique; crossed intrinsic trans... |
| Fc | centroid frequency; fraction/centrifuge; fragment, crystallizable [of immunoglobulin] |
| Fc' | a fragment of an immunoglobulin molecule produced by papain digestion |
| immunoglobulin isotypes | The classes of immunoglobulins found in any species of animal. In man there are nine classes that migrate in five different groups in electrophoresis; they each consist of two light and two heavy protein chains, and each group has distinguishing structural and functional properties. (12 Dec 1998) |
|---|---|
| immunoglobulin joining region | Segment of light and heavy chains of mouse and human immunoglobulins where the genes for the variable region upstream join those of the constant region downstream (an important part of the antibody diversity mechanism). In the joining region of the light chain are the genes coding for amino acids 96 to 107. (12 Dec 1998) |
| immunoglobulin M | <immunology> An immunoglobulin M molecule (970 kD) is built up from five immunoglobulin G type monomers joined together, with the assistance of J chains, to form a cyclic pentamer. Immunoglobulin M binds complement and a single molecule bound to a cell surface can lyse that cell. Immunoglobulin M is usually produced first in an immune response before immunoglobulin G. The human red cell isoantibodies are immunoglobulin M antibodies. Heavy chain (mu chain) is rather larger than the heavy chains of other immunoglobulins. (30 Mar 1998) |
| immunoglobulin superfamily | <immunology> A large group of proteins with immunoglobulin like domains. most are involved with cell surface recognition events. Sequence homologyy suggests that immunoglobulins, MHC molecules, some cell adhesion molecules and cytokines receptors share close homology and thus belong to a multigene family. (30 Mar 1998) |
| immunoglobulin switch region | Site on a segment of a B-cell immunoglobulin heavy-chain gene where recombination or rearrangement can occur, expressed as isotype or allotype switching, maturation of immune response, or recombination of DNA molecules. It is found on genes encoding all five immunoglobulin heavy chains. (12 Dec 1998) |
| immunoglobulin variable region | That region of the immunoglobulin (antibody) molecule that varies in its amino acid sequence and composition, confers the antigenic specificity, and is thought to comprise the binding site for the antigen. It is located at the n-terminus of the fab fragment of the immunoglobulin. It includes hypervariable and framework regions, vh family subgroups, and the complementarity-determining region. (12 Dec 1998) |
| intravenous immunoglobulin | <pharmacology> A sterile solution of concentrated antibodies extracted from healthy people. IVIG is used to prevent bacterial infections in people with low or inappropriate antibody production. Injected into a vein or muscle. (09 Oct 1997) |
| tetanus immunoglobulin | <protein> A protein antibody to tetanus toxin, given as passive immunity for those lacking any prior tetanus vaccination. (27 Sep 1997) |
| thyroid stimulating immunoglobulin | <protein> A test that measures the amount of an antibody (thyroid stimulating antibody) which is directed against a receptor for TSH on the thyroid gland. This antibody acts like TSH and stimulates the thyroid to produce excessive amounts of thyroid hormone. The presence of this antibody generally indicates Grave's disease (hyperthyroidism). (27 Sep 1997) |
| amniotic fold | A fold of amniotic membrane enclosing the yolk stalk and extending from the point of insertion of the umbilical cord to the yolk sac; in reptiles and birds it is the reflected edge of the amnion where it folds over to cover the embryo during early development. Synonym: Schultze's fold. (05 Mar 2000) |
| anterior axillary fold | Bounds axilla anteriorly; formed by skin and fascia overlying inferior border of pectoralis major muscle. (05 Mar 2000) |
| aryepiglottic fold | A prominent fold of mucous membrane stretching between the lateral margin of the epiglottis and the arytenoid cartilage on either side; it encloses the aryepiglottic muscle. Synonym: plica aryepiglottica. (05 Mar 2000) |
| axillary fold | One of the folds of skin and muscular tissue bounding the axilla anteriorly and posteriorly. Synonym: plica axillaris. (05 Mar 2000) |
| palpebronasal fold | A fold of skin that comes down across the inner angle of the eye. The epicanthal fold is more common in children with Down syndrome and other birth defects than normal children and so is of value in diagnosis. Although some dictionaries state that this eye fold is found in peoples of Asian origin, this is not true. The normal Asian eyefold is continuous with the lower edge of the upper eyelid and actually appears distinctly different than a true epicanthal fold. (12 Dec 1998) |
| vascular fold of the caecum | <anatomy> A peritoneal fold that arches over a branch of the ileocolic artery and bounds in front a narrow recess, the superior ileocaecal (or ileocolic) recess. Synonym: plica caecalis vascularis. (05 Mar 2000) |