| 영문 | gene therapy | 한글 | 유전자요법 |
|---|---|---|---|
| 설명 | 유전병을 치료할 목적으로, 정상적으로 기능하는 단일유전자 혹은 복수유전자를 어떤 기원에서 얻어내어 생세포에 도입하는 것. 유전물질은 유전자삽입 조작에 의해 수용세포에로 도입된다. 즉, 유전자를 끼워 넣은 새로운 세포를 사용하는 치료로서 1980년 미국의 학자가 지중해빈혈환자에게 강행하여 비판을 받았지만, 미국 국립보건연구소는 1990년 9월 아데노신 데아미나아제(adenosine deaminase, ADA) 결핍증 환자의 림프구에 ADA 유전자를 끼워 넣는 치료를 시작한 이래 현재는 암을 포함한 많은 질병들을 치료하는 목적으로 쓰인다. |
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| 영문 | Electric convulsive therapy(ECT) | 한글 | 전기경련요법 |
|---|---|---|---|
| 설명 | 뇌에 전기 자극을 주어 인위적으로 경련을 유발함으로써 정신 병을 치료하는 방법. 전기쇼크요법(electroshock therapy)이라고도 한다. 1938년에 이탈리아의 체를레티와 비니에 의해 시작되었다. 작용기전은 확실치 않으나 뇌의 신진대사, 생화학 및 효소 등에 변화를 일으킨다는 생물학적, 생화학적 학설이 유력하다. 적응증으로 가장 효과적인 병은 우울증으로 특히 여성에서 갱년기에 호발하는 갱년기 우울증, 우울증과 조증(아주 기분이 좋은 상태가 지속되는 정신병)이 일정한 주기를 두고 반복하는 조울증에 잘 쓰이며, 80~90%에서 효과가 있다. |
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| immune deficiency diseases | Those diseases in which immune reactions are suppressed or reduced. Reasons may include congenital absence of B and/or T lymphocytes or viral killing of helper lymphocytes (see HIV). (18 Nov 1997) |
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| immune deviation | Modification of an immune response to an antigen after prior exposure to that antigen. Synonym: split tolerance. (05 Mar 2000) |
| immune electron microscopy | Electron microscopy of biological specimens to which specific antibody has been bound. (05 Mar 2000) |
| immune haemolysin | A sensitizing, complement-fixing, haemolytic antibody formed in an animal as the result of parenteral administration of red blood cells or whole blood from another species; immune haemolysin may also be formed in human beings who are transfused with human blood that is antigenic in the recipient, e.g., the formation of anti-Rh antibody in an Rh-negative person who is treated with Rh-positive red blood cells. (05 Mar 2000) |
| immune haemolysis | Haemolysis caused by complement when erythrocytes have been sensitised by specific complement-fixing antibody. Synonym: conditioned haemolysis. (05 Mar 2000) |
| immune inflammation | See: allergic reaction. (05 Mar 2000) |
| immune interferon | <cytokine> Interferon elaborated by T lymphocytes in response to either specific antigen or mitogenic stimulation. This type II interferon can be produced by recombinant DNA technology and is similar to the interferon secreted by lymphocytes and has antiviral and antineoplastic activity. Synonym: antigen interferon, immune interferon. Pharmacological action: antineoplastic agent, antiviral agents. (20 Sep 2002) |
| immune opsonin | specific opsonin |
| immune paralysis | The induction of tolerance in mice due to injection of large amounts of polysaccharide. The polysaccharide is poorly metabolised and the paralysis remains only during the persistence of the above. (05 Mar 2000) |
| immune precipitation | <immunology> The precipitation of a multivalent antigen by a bivalent antibody, resulting in the formation of a large complex. The antibody and antigen must be soluble. Precipitation usually occurs when there is near equivalence between antibody and antigen concentrations. (18 Nov 1997) |
| immune protein | An immunoglobulin molecule that has a specific amino acid sequence by virtue of which it interacts only with the antigen that induced its synthesis in cells of the lymphoid series (especially plasma cells) or with antigen closely related to it. Antibodies are classified according to their ode of action as agglutinins, bacteriolysins, haemolysins, opsonins, precipitins, etc. (18 Nov 1997) |
| immune reaction | Antigen-antibody reaction indicating a certain degree of resistance, usually in reference to the 36-to 48-hour reaction in vaccination against smallpox; because the degree of resistance indicated by the reaction is not true immunity and may disappear relatively rapidly there is a tendency to refer to the immune reaction as an allergic reaction. (05 Mar 2000) |
| immune response | <immunology> Alteration in the reactivity of an organisms immune system in response to an antigen, in vertebrates, this may involve antibody production, induction of cell-mediated immunity, complement activation or development of immunological tolerance. (18 Nov 1997) |
| immune-response gene | <molecular biology> Any of several genes of the major histocompatibility complex that control the immune response of lymphocytes to specific antigens. (09 Oct 1997) |
| immune response genes | Gene's in the HLA-D region of the histocompatibility complex of human chromosome 6 which control the immune response to specific antigens. (05 Mar 2000) |