| AMPA | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; American Medical Publishers Association |
|---|---|
| diBr-HQ | 5,7-dibromo-8-hydroxy-quinidine |
| EHDP | ethane-1-hydroxy-1,1-diphosphate |
| EHNA | 9-erythro-2-(hydroxy-3-nonyl) adenine |
| GOBAB | gamma-hydroxy-beta-amino-butyric acid |
| ion pumps | Integral membrane proteins that transport ions across a membrane against an electrochemical gradient. (12 Dec 1998) |
|---|---|
| ion selective electrode | An electrode half cell, with a semi permeable membrane that is permeable only to a single ion. The electrical potential measured between this and a reference half cell (e.g. A calomel electrode) is thus the Nernst potential for the ion. Given that the solution filling the ion selective electrode is known, the activity (rather than concentration) of the ion in the unknown solution can be measured. Commercial ion selective electrodes frequently use a hydrophobic membrane containing an ionophore, such as valinomycin (for potassium) or monensin (for sodium). A pH electrode is made with a thin membrane of pH sensitive (i.e. Proton permeable) glass. (18 Nov 1997) |
| ion-selective electrodes | Electrodes which can be used to measure the concentration of particular ions in cells, tissues, or solutions. (12 Dec 1998) |
| ion transport | The movement of ions across energy-transducing cell membranes. Transport can be active or passive. Passive ion transport (facilitated diffusion) derives its energy from the concentration gradient of the ion itself and allows the transport of a single solute in one direction (uniport). Active ion transport is usually coupled to an energy-yielding chemical or photochemical reaction such as ATP hydrolysis. This form of primary active transport is called an ion pump. Secondary active transport utilises the voltage and ion gradients produced by the primary transport to drive the cotransport of other ions or molecules. These may be transported in the same (symport) or opposite (antiport) direction. (12 Dec 1998) |
| oxonium ion | <chemistry> A positively charged ion that is water with an additional hydrogen atom (H3O). (09 Oct 1997) |
| tetraethylammonium ion | A monovalent cation widely used in neurophysiology as a specific blocker of potassium channels. It is similar in size to the hydrated potassium ion and gets stuck (reversibly) in the channels. (18 Nov 1997) |
| field ion microscope | <instrument> Type of microscopy in which the specimen is illuminated with ions, often gallium ions, that are focussed electrostatically. The ions remove components of the specimen, lower atomic masses first. These are imaged and provide information on elemental distribution with a resolution of perhaps 30 nm. (18 Nov 1997) |
| ligand gated ion channel | A transmembrane ion channel whose permeability is increased by the binding of a specific ligand, typically a neurotransmitter at a chemical synapse. The permeability change is often drastic, such channels let through effectively no ions when shut, but allow passage at up to 10exp7 ions sexp 1 when a ligand is bound. Recently, the receptors for both acetylcholine and GABA have been found to share considerable sequence homology, implying that there may be a family of structurally related ligand gated ion channels. (18 Nov 1997) |
| light-ion fusion | <radiobiology> Light-Ion-Beam-Driven Inertial Confinement fusion, using beams of light ions driven at implosion targets. Pulsed-power driven accelerators are relatively efficient and cost-effective, but beam-focusing is a technical hurdle for this approach. (09 Oct 1997) |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | <chemical> Alpha-amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid. An ibotenic acid homolog and glutamate agonist. The compound is the defining agonist for the ampa subtype of glutamate receptors (receptors, ampa). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies. Pharmacological action: excitatory amino acid agonists. Chemical name: 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo- (12 Dec 1998) |
| beta-hydroxy-beta-methylglutaryl-CoA | -OOCCH2C(OH)(CH3)CH2COS-CoA;a key intermediate in the synthesis of ketone bodies and of steroids. Synonym: 3-hydroxy-3-methylglutaryl-CoA. Beta-hydroxy-beta-methylglutaryl-lyase, an enzyme, found primarily in liver and rumen epithelium that catalyses the formation of acetyl-CoA and acetoacetate from beta-hydroxy-beta-methylglutaryl-CoA; a key step in ketogenesis; a deficiency of this enzyme leads to episodes of severe metabolic acidosis without ketosis. Beta-hydroxy-beta-methylglutaryl-reductase, an enzyme that catalyses the rate-limiting step of cholesterol biosynthesis, beta-hydroxy-beta-methylglutaryl-CoA + 2NADPH + 2H+ → mevalonate + 2NADP+ + coenzyme A. Beta-hydroxy-beta-methylglutaryl-synthase, an enzyme in mitochondria that catalyses the reaction of acetyl-CoA with acetoacetyl-CoA and water to form beta-hydroxy-beta-methylglutaryl-CoA and coenzyme A, a step required for both ketogenesis and steroidogenesis to occur. (05 Mar 2000) |
| calcium hydroxy apatite | <radiology> All calcification in soft tissues is hydroxyapatite, except cartilage (chondrocalcinosis): calcium pyrophosphate see also: Milwaukee shoulder (12 Dec 1998) |
| chromatin 3'-phosphatase-5'-hydroxy kinase | <enzyme> Hydrolyzes the 3'-phosphate end of a polynucleotide duplex followed by ATP-mediated phosphorylation of the 5'-oh end Registry number: EC 3.1.3.- Synonym: chromatin-phosphatase-hydroxykinase (26 Jun 1999) |
| S-adenosyl-L-methionine-2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase | <enzyme> Proposed pathway for final reaction in ubiquinone biosynthesis. Registry number: EC 2.1.1.- Synonym: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, ubig gene product, ubig protein (26 Jun 1999) |
| hydroxy- | <chemistry, prefix> A combining form, also used adjectively, indicating hydroxyl as an ingredient. <chemistry> Hydroxy acid, an organic acid, having (besides the hydroxyl group of the carboxyl radical) an alcoholic hydroxyl group, and thus having the qualities of an alcohol in addition to its acid properties; as, lactic and tartaric acids are hydroxy acids. (29 Oct 1998) |