| DOB | date of birth; doctor's order book |
|---|---|
| HTO | hospital transfer order |
| OC | obstetrical conjugate; occlusocervical; office call; on call; only child; optic chiasma; oral contra... |
| OE | on examination; order entry [system]; orofacial cleft; orthopedic examination; otitis externa; out-s... |
| POE | pediatric orthopedic examination; physician order entry; point of entry; polyoxyethylene; postoperat... |
| topographic map | <anatomy, neurology> The spatially ordered projection of neurons onto their target, for example in the retino tectal projection, retinal ganglion cell axons project along the optic nerve to the contralateral tectum where they ramify to form terminal arbors. The target sites of the terminal arbors are ordered: neurons from a specific region of the retina consistently project to a specific region of the tectum, forming a map of the retina on the tectum. (18 Nov 1997) |
|---|---|
| y map | The array of genes on the y chromosome. Once thought to be a genetic wasteland, the y now is known to contain at least 20 genes, some of them unique to the y including the male-determining gene and male fitness genes that are active only in the testis and are thought responsible for the formation of sperm. Other genes on the y have counterparts on the x chromosome, are active in many body tissues and play crucial housekeeping roles with the cell. (12 Dec 1998) |
| fate map | <embryology> Diagram of an early embryo (usually a blastula) showing which tissues the cells in each region will give rise to (i.e. Their developmental fate). Fate maps are normally constructed by labelling small groups of cells in the blastula with vital dyes and seeing which tissues are stained when the embryo develops. (18 Nov 1997) |
| linkage map | <genetics> A map of the relative positions of genetic loci on a chromosome, determined onthe basis of how often the loci are inherited together. Distance ismeasured in centimorgans (cM). (09 Oct 1997) |
| allelic gene | See: allele, dominance of traits. (05 Mar 2000) |
| antibiotic resistance gene | Genes in a microorganism which confer resistance to antibiotics, for example by coding for enzymes which destroy it, by coding for surface proteins which prevent it from entering the microorganism, or by being a mutant form of the antibiotic's target so that it can ignore it. (09 Oct 1997) |
| autosomal gene | A gene located on any chromosome other than the sex chromosomes (X or Y). (05 Mar 2000) |
| bicoid gene | A group of genes which are important to the proper development of the head and thorax in the embryo of the fruit fly Drosophila melanogaster. (09 Oct 1997) |
| BRCA1 breast cancer susceptibility gene | This mutated (changed) version of the BRCA1 gene makes a person susceptible to developing breast cancer. (12 Dec 1998) |
| calcitonin gene-related peptide | <protein> A second product transcribed from the calcitonin gene. Calcitonin gene related peptide is found in a number of tissues including nervous tissue. It is a vasodilator that may participate in the cutaneous triple response. It is a neuropeptide of 37 amino acids with structural homology to salmon calcitonin. Co-localises with substance P in neurons. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in neural tissue of the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. Intracerebral administration leads to a rise in noradrenergic sympathetic outflow, a rise in blood pressure and a fall in gastric secretion. Acronym: CGRP (05 May 2002) |
| cancer susceptibility gene | tumour suppressor gene |
| rab gene | 1. <molecular biology> One of the three main groups of ras like genes specifying small GTP-binding proteins (the others are ras and rho). Rab proteins are involved in vesicular traffic and seem to control translocation from donor to acceptor membranes. 2. <cell biology> Gene family in plants responsive to abscisic acid: encode proteins of 15-17 kD. (18 Nov 1997) |
| pair rule gene | <molecular biology> A segmentation gene, expressed sequentially between gap genes and segment polarity genes. In development of Drosophila, a set of about 8 genes that are expressed only in alternate segments (odd or even) of the developing embryo. Loss of function mutants thus lack alternate segments. Examples: even skipped (eve), fushi tarazu (ftz), hairy. (18 Nov 1997) |
| variable gene | <molecular biology> Those regions in the amino acid sequence of both the heavy and the light chains of immunoglobulins where there is considerable sequence variability from one immunoglobulin to other of the same class, in contrast to constant sequence (C) regions. The V regions are associated with the antigen binding areas. They contain hypervariable regions of particularly high sequence diversity. (18 Nov 1997) |
| gap gene | <molecular biology> Segmentation genes involved in specifying relatively coarse subdivisions of the embryo. They are expressed sequentially in development between egg polarity genes and pair rule genes. In Drosophila, there are at least three such genes, for example Kruppel. (18 Nov 1997) |