| vibration tolerance | The maximum vibratory or oscillatory movements that an individual can experience and bear without pain; the limit of tolerance is a function of amplitude and frequency of the vibration and varies with the direction of application. (05 Mar 2000) |
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| glucose tolerance factor | A water-soluble complex containing chromium needed for normal glucose tolerance. (05 Mar 2000) |
| glucose tolerance test | <chemical pathology, investigation> A special test where the blood glucose is measure in intervals after a glucose-rich meal is taken, a test used for diagnosing diabetes. (27 Sep 1997) |
| work schedule tolerance | Physiological or psychological effects of periods of work which may be fixed or flexible such as flexitime, work shifts, and rotating shifts. (12 Dec 1998) |
| cross tolerance | <pharmacology> The resistance to one or several effects of a compound as a result of tolerance developed to a pharmacologically similar compound. (05 Mar 2000) |
| high dose tolerance | The induction of tolerance by exposure to high doses of antigen. (05 Mar 2000) |
| xylose tolerance test | <investigation> This test measures the intestine's ability to absorb the simple sugar, D-xylose. This is an indicator for whether or not nutrients are being absorbed properly in the intestine. This test is often used to evaluate persistent diarrhoea, weight loss, malnutrition and cases of suspected malabsorption. Abnormal results may be seen in the following conditions: Crohn's disease, Giardiasis, hookworm infestation, radiation enteritis, celiac sprue, viral gastroenteritis and Whipple's disease. (27 Sep 1997) |
| self tolerance | The normal lack of the ability to produce an immunological response to autologous (self) antigens. A breakdown of self tolerance leads to autoimmune diseases. The ability to recognise the difference between self and non-self is the prime function of the immune system. (12 Dec 1998) |
| species tolerance | The insensitivity to a particular drug exhibited by a particular species. (05 Mar 2000) |
| split tolerance | Modification of an immune response to an antigen after prior exposure to that antigen. Synonym: split tolerance. (05 Mar 2000) |
| nonresponder tolerance | Lack of immune response to antigen. Theories of tolerance induction include clonal deletion and clonal anergy. In clonal deletion, the actual clone of cells is eliminated whereas in clonal anergy the cells are present but nonfunctional. Synonym: immunological tolerance, immunotolerance, nonresponder tolerance. (05 Mar 2000) |
| drug tolerance | Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from drug resistance wherein a human, animal, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. (12 Dec 1998) |
| immune tolerance | The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (foetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc. (12 Dec 1998) |
| immunological tolerance | <immunology> Specific unresponsiveness to antigen. Self tolerance is a process occurring normally early in life due to suppression of self reactive lymphocyte clones. Tolerance to foreign antigens can be induced in adult life by exposure to antigens under conditions in which specific clones are suppressed. Note that tolerance is not the same as immunological unresponsiveness, since the latter may be very non-specific as in immunodeficiency states. (18 Nov 1997) |
| immunologic high dose tolerance | Induction of tolerance by exposure to large amounts of protein antigens. (05 Mar 2000) |