| drug development pathway | The various procedures and studies that must be undertaken to satisfy Food and Drug Administration requirements for drug approval and marketing. (14 Nov 1997) |
|---|---|
| intrinsic pathway | <haematology> Initiation of blood clotting as a result of factors released from damaged tissue, as opposed to contact with a foreign surface (the intrinsic pathway). Tissue thromboplastin (Factor III) in conjunction with Factor VII proconvertin) will activate Factor X that, once activated, converts prothrombin to thrombin. (27 Jun 1999) |
| Embden-Meyerhof-Parnas pathway | A pathway that degrades glucose to pyruvate, the six-carbon stage converts glucose to fructose-1,6-bisphosphate, and the three-carbon stage produces ATP while changing glyceraldehyde-3-phosphate to pyruvate. Compare: Entner-Doudoroff pathway. (09 Oct 1997) |
| Embden-Meyerhof pathway | The main pathway for anerobic degradation of carbohydrate. Starch or glycogen is hydrolysed to glucose 1 phosphate and then through a series of intermediates, yielding two ATP molecules per glucose and producing either pyruvate which feeds into the tricarboxylic acid cycle) or lactate. (18 Nov 1997) |
| Entner-Douderoff pathway | A degradative pathway for carbohydrates in certain microorganisms (e.g., Pseudomonas sp.) that lack hexokinase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase. (05 Mar 2000) |
| Entner-Doudoroff pathway | <biochemistry> A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it. (09 Oct 1997) |
| extrinsic pathway | <haematology> Initiation of blood clotting as a result of factors released from damaged tissue, as opposed to contact with a foreign surface (the intrinsic pathway). Tissue thromboplastin (Factor III) in conjunction with Factor VII proconvertin) will activate Factor X that, once activated, converts prothrombin to thrombin. (27 Jun 1999) |
| 4-aminobutyrate pathway | The pathway that ultimately converts 4-aminobutyrate to succinate; succinate is then converted to alpha-ketoglutarate, via the tricarboxylic acid cycle, which is then acted upon by glutamate dehydrogenase; glutamate is then decarboxylated to reform 4-aminobutyrate; an important pathway for those cells which make this neuroactive molecule. Synonym: GABA pathway. (05 Mar 2000) |
| lysogenic pathway | <virology> The method by which a virus becomes a dormant, passive part of its host bacterium's genome (a lysogenic virus), choosing to insert its DNA into the host's and postponing completion of its lytic cycle, at which time it destroys the host and spreads its progeny to infect other bacterial cells (enters the lytic pathway). (09 Oct 1997) |
| lytic pathway | The steps in the method that a virus takes to complete a lytic cycle, including the production and assembly of progeny viruses with host cell machinery and the destruction of the host cell by rupturing its plasma membrane (lysis), releasing the progeny viruses in the process. (09 Oct 1997) |
| carotid artery, common | The two principal arteries supplying the structures of the head and neck. They ascend in the neck, one on each side, and at the level of the upper border of the thyroid cartilage, each divides into two branches, the external (carotid artery, external) and internal (carotid artery, internal) carotid arteries. (12 Dec 1998) |
| migraine, common | Migraine without aura. The most frequent type, accounting for about 80-85% of migraines. See migraine. (12 Dec 1998) |
| cold, common | A viral upper respiratory tract infection. A contagious illness caused by a number of different types of viruses. Because of the great number of viruses that can cause a cold, the body never builds up resistance (immune) against all of them. For this reason, colds are a frequent and recurring problem. In fact, preschool children average 9 colds a year; those in kindergarten, 12 colds a year; and adolescents and adults, 7 colds per year. Going out into the cold weather has no effect on the spread of a cold. Antibiotics do not help the common cold. (12 Dec 1998) |
| common acute lymphoblastic leukaemia | <haematology, oncology> A sub-type of acute lymphoblastic leukaemia affecting cells early in the B lymphocyte lineage which accounts for about 80% of all acute lymphoblastic leukaemia. Origin: Gr. Haima = blood (13 Nov 1997) |
| common antigen | Cross reacting antigen (epitope), a common antigen that occurs in 2 or more different molecules/organisms. Synonym: heterogenic enterobacterial antigen. (05 Mar 2000) |