| CMI | carbohydrate metabolism index; care management integration; case mix index; cell-mediated immunity; ... |
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| DMI | Defense Mechanism Inventory; Diagnostic Medical Instruments; diaphragmatic myocardial infarction; di... |
| EAI | Emphysema Anonymous, Inc.; erythrocyte antibody inhibition |
| ff+ | fertility inhibition positive |
| ff- | fertility inhibition negative |
| haptenic inhibition | <immunology, molecular biology> Could be considered an isolated epitope: although a hapten (by definition) has an antibody directed against it, the hapten alone will not induce an immune response if injected into an animal, it must be conjugated to a carrier (usually a protein). The hapten constitutes a single antigenic determinant, perhaps the best known example is dinitro phenol (DNP) that can be conjugated to BSA and against which antiDNP antibodies are produced (antibodies to the BSA can be adsorbed out). Because the hapten is monovalent, immune complex formation will be blocked if the soluble hapten is present as well as the hapten carrier conjugate (assuming there is more than one hapten per carrier then an immune precipitate can be formed). Competitive inhibition by the soluble small molecule is sometimes referred to as haptenic inhibition and this term has carried over into lectin mediated haemagglutination where monosaccharides are added to try to block haemagglutination: the blocking sugar defines the specificity of the lectin. (18 Nov 1997) |
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| hapten inhibition of precipitation | Inhibition of precipitation that occurs when the precipitin has combined with hapten of the same specificity as the subsequently added antigen. (05 Mar 2000) |
| proactive inhibition | The state or process hypothesised to account for poorer learning rate for elements later in a series as compared to the learning rate for elements coming earlier in a series. (12 Dec 1998) |
| product inhibition | Inhibition of an enzyme activity by a product of the reaction catalyzed by that enzyme. (05 Mar 2000) |
| selective inhibition | <chemistry> Inhibitor that occupies the active site of an enzyme or the binding site of a receptor and prevents the normal substrate or ligand from binding. at sufficiently high concentration of the normal ligand inhibition is lost: the Km is altered by the competitive inhibitor, but the Vmax remains the same. (05 Jan 1998) |
| noncompetitive inhibition | <chemistry> A form of enzyme inhibition which cannot be reversed by increasing the amount of substrate in the reaction. (09 Oct 1997) |
| substrate inhibition | Inhibition of an enzyme activity by a substrate of the reaction catalyzed by that enzyme; often, this type of inhibition occurs at elevated substrate levels in which the substrate is binding to a second, non-active site on the enzyme. (05 Mar 2000) |
| nonreciprocal contact inhibition | <cell biology> Collision behaviour between different cell types in which one cell shows contact inhibition of locomotion and the other does not. An example is the interaction between sarcoma cells and fibroblasts (the former not being inhibited). (18 Nov 1997) |
| density dependent inhibition of growth | <cell culture> The phenomenon exhibited by most normal (anchorage dependent) animal cells in culture that stop dividing once a critical cell density is reached. The critical density is considerably higher for most cells than the density at which a monolayer is formed, for this reason, most cell behaviourists prefer the term density dependent inhibition of growth as this avoids any confusion with contact inhibition of locomotion, a totally different phenomenon that is contact dependent. (12 Jan 1998) |
| inhibition | 1. Arrest or restraint of a process. 2. <psychology> The interference with or prevention of a behavioural or verbal response even though the stimulus for that response is present; in psychoanalysis the unconscious restraining of an instinctual process. Origin: L. Inhibere = to restrain, habere = to hold (04 Jul 1999) |
| inhibition factor | <growth factor> A soluble, nondialysable factor that is produced by sensitised lymphocytes following exposure to a specific antigen. It inhibits macrophage migration and causes adherence. It was originally defined on the basis of inhibition of emigration of mononuclear cells from capillary (haematocrit) tubes, more recently a 13 kD protein with migration inhibitory activity has been isolated. Acronym: MIF Synonym: inhibition factor. (22 Sep 2002) |
| tissue thromboplastin inhibition time | A test used to identify lupus anticoagulant; the thromboplastin source used in the prothrombin test is diluted to increase sensitivity to inhibitors. (05 Mar 2000) |
| end product inhibition | <biochemistry, physiology> The process of the end product of a particular metabolic reaction inhibiting an allosteric enzyme involved in that reaction as the reaction starts again, thus breaking the reaction cycle. (09 Oct 1997) |
| enzyme inhibition theory of narcosis | That narcotics inhibit respiratory enzymes by suppression of the formation of high energy phosphate bonds within the cell. (05 Mar 2000) |
| uncompetitive inhibition | An inhibitory effect on a metabolic function, such as an enzyme, not based on competition for the binding site of the naturally occurring substrate, but on a different effect on the molecule whose function is being inhibited. (05 Mar 2000) |