| cystic disease of renal medulla | Presence of small cysts in the renal medulla associated with anaemia, sodium depletion, and chronic renal failure. It is of two types: 1) fatal autosomal recessive or juvenile type (also called familial juvenile nephrophthisis), beginning at about age 10 with an average duration of 6 to 8 years; 2) autosomal dominant or adult type, beginning at about age 30 but with a more fulminant course. Synonym: microcystic disease of renal medulla. (05 Mar 2000) |
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| cystic fibrosis | <chest medicine> A generalised disorder of infants, children and young adults, in which there is widespread dysfunction of the exocrine glands, characterised by signs of chronic pulmonary disease (due to excess mucus production in the respiratory tract), pancreatic deficiency, abnormally high levels of electrolytes in the sweat and occasionally by biliary cirrhosis. There is an ineffective immunologic defense against bacteria in the lungs. Pathologically, the pancreas shows obstruction of the pancreatic ducts by amorphous eosinophilic concretions, with consequent deficiency of pancreatic enzymes, resulting in steatorrhoea and azotorrhoea and intestinal malabsorption. The degree of involvement of organs and glandular systems may vary greatly, with consequent variations in the clinical picture. Inheritance: autosomal recessive. (13 Nov 1997) |
| cystic fibrosis antigen | Now known to be MRP 8. See: calgranulins. (18 Nov 1997) |
| cystic fibrosis transmembrane conductance regulator | Gene believed to be defective in cystic fibrosis. Gene encodes a chloride channel, homologous to a family of proteins that actively transport small solutes in an ATP dependent manner (ABC transporters). The regulator protein is a protein which is embedded in the cell membrane and acts as a channel for certain ions to be transported into or out of the cell. The disease cystic fibrosis is caused by a defect in the gene for this protein. (09 Oct 1997) |
| cystic goiter | An enlargement in the thyroid region due to the presence of one or more cysts within the gland. (05 Mar 2000) |
| cystic hygroma | <radiology> Multiple cystic structures in nuchal region, lack of communication btw cervical lymphatics and venous system, unlike encephalocele: no cranial defect, no vertebral anomaly associated with: Turner syndrome, Roberts syndrome (single-gene disorder), Down syndrome (12 Dec 1998) |
| cystic hyperplasia | Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium, as in fibrocystic disease of the breast and metropathia haemorrhagica. (05 Mar 2000) |
| cystic hyperplasia of the breast | A benign disease common in women of the third, fourth, and fifth decades characterised by formation, in one or both breasts, of small cysts containing fluid which may appear as blue dome cysts; associated with stromal fibrosis and with variable degrees of intraductal epithelial hyperplasia and sclerosing adenosis. Synonym: cystic hyperplasia of the breast. (05 Mar 2000) |
| cystic kidney | A general term used to indicate a kidney that contains one or more cysts, including polycystic disease, solitary cyst, multiple simple cysts, and retention cysts (associated with parenchymal scarring). (05 Mar 2000) |
| cystic liver metastases | <radiology> Mucinous ovarian carcinoma, colonic carcinoma, sarcoma, melanoma, lung carcinoma, carcinoid tumour see: liver metastases (12 Dec 1998) |
| cystic lymphangiectasis | A condition characterised by a fairly well circumscribed group of several or numerous, cystlike, dilated vessels or spaces lined with endothelium and filled with lymph. Synonym: cystic lymphangiectasis. (05 Mar 2000) |
| cystic lymph node | A lymph node at the neck of the gallbladder draining lymph into the hepatic nodes. Synonym: nodus cysticus, cystic node. (05 Mar 2000) |
| cystic medial necrosis | Loss of elastic and muscle fibres in the aortic media, with accumulation of mucopolysaccharide, sometimes in cystlike spaces between the fibres; a disease of unknown cause, which may be inherited and which predisposes to dissecting aneurysms. Synonym: Erdheim disease, medionecrosis aortae idiopathica cystica, medionecrosis of the aorta, mucoid medial degeneration. (05 Mar 2000) |
| cystic mole | <gynaecology, oncology, tumour> A relatively rare mass or tumour that can form within the uterus at the beginning of a pregnancy. The cause of hydatidiform mole is unknown. Symptoms include vaginal bleeding, uterine growth, nausea and vomiting. Some hydatidiform moles may become malignant (cancerous) where they are referred to as a choriocarcinoma. Incidence: 1 in 1,500 births. (02 Jan 1998) |
| cystic node | A lymph node at the neck of the gallbladder draining lymph into the hepatic nodes. Synonym: nodus cysticus, cystic node. (05 Mar 2000) |