| complement cytolysis inhibitor | <protein> Vertebrate glycoprotein of uncertain function. Secreted as a 400 amino acid peptide, then cleaved to form two 200 amino acid peptides that are linked by a disulphide bridge. Synonym: complement associated protein, complement cytolysis inhibitor, glycoprotein III. (11 Jan 1998) |
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| complement factor h | <chemical> A beta-globulin that binds to complement 3b and makes ic3b (inactivated complement 3b) susceptible to cleavage by complement factor I. Complement factor h also acts as an alternative pathway complement inhibitor by interfering with the binding of properdin factor b to c3b. Chemical name: Complement factor H (12 Dec 1998) |
| complement factor I | <enzyme> Serine proteinase that acts on ic3b (inactivated complement 3b) to cleave it into c3c and c3dg with the help of a trypsin-like proteolytic enzyme. Complement factor I was formerly called kaf, c3binf, or enzyme 3b inactivator. Registry number: EC 3.4.21.45 (12 Dec 1998) |
| complement fixation | <immunology> Binding of complement as a result of its interaction with immune complexes (the classical pathway) or particular surfaces (alternative pathway). (18 Nov 1997) |
| complement fixation tests | Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualised by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (haemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1. (12 Dec 1998) |
| complement haemolytic activity assay | Usual screening assay for complement. Dilutions of the serum to be tested are added to antibody-coated erythrocytes and the percentage of lysis is measured. The values are expressed by ch50, haemolytic complement units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay. (12 Dec 1998) |
| complement inactivators | Serum proteins which act at key sites in the complement sequence to modulate or prevent the progression of the reaction. Absence of these factors leads to uncontrolled activation of the complement system with accompanying disease. (12 Dec 1998) |
| complement membrane attack complex | The assembly of complement plasma glycoproteins c5b, c6, c7, c8, and polymeric c9 as a group on biological membranes. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The formation of the membrane attack complex is the terminal step in the complement cascade. (12 Dec 1998) |
| complement pathway, alternative | The complement activation sequence initiated by the activation of complement factor c3, which is triggered by the interaction of microbial polysaccharides and properdin without participation of an antigen-antibody reaction. (12 Dec 1998) |
| complement pathway, classical | The sequential activation of complement, initiated by antigen-antibody complex and the binding of complement factor c1q to the fc region of the antibody. (12 Dec 1998) |
| complement system | A group of more than 20 serum proteins, some of which can be serially activated and participate in a cascade resulting in cell lysis. (05 Mar 2000) |
| complement unit | The smallest amount (highest dilution) of complement that will cause haemolysis of a unit of red blood cells in the presence of a haemolysin unit. Synonym: alexin unit. (05 Mar 2000) |
| complement-fixation reaction | <immunology> Binding of complement as a result of its interaction with immune complexes (the classical pathway) or particular surfaces (alternative pathway). (18 Nov 1997) |
| complement-fixation test | An immunological test for determining the presence of a particular antigen or antibody when one of the two is known to be present, based on the fact that complement is "fixed" in the presence of antigen and its specific antibody. See: Bordet-Gengou phenomenon. (05 Mar 2000) |
| complement-fixing antibody | Antibody that combines with and sensitises antigen leading to the activation of complement, which may result in cell lysis. Synonym: CF antibody, sensitizing substance. (05 Mar 2000) |
Synonyms : C2b Complement, Complement 2b, Complement C2b Fragment, Complement Component 2b, C2b Fragment, Complement, C2b, Complement, Complement, C2b, Component 2b, Complement, Fragment, Complement C2b
Synonyms : C3 Complement, C3 Precursor, Complement 3, Complement C3 Precursor, Complement Component 3, Precursor-Complement 3, Pro-C3, Pro-Complement 3, C3 Precursor, Complement, C3, Complement, Complement, C3, Component 3, Complement, Precursor Complement 3, Precursor, C3
Synonyms : Alternative Pathway C3 Convertase, C3 Convertase (C3bBb), C3 Convertase, Alternative Pathway, CVFBb, Complement 3 Convertase, Alternative Pathway, Complement 3b-Associated Factor B-fragment Bb, Complement C3 Convertase, CVFBb
Synonyms : C3 Convertase (C4b2a), Classical C3 Convertase, Classical Pathway C3 Convertase, C3 Convertase, Classical
Synonyms : C 3 Nephritic Factor, C3 Nephritic Factor, Complement 3 Nephritic Factor
| complex |
a conceptual whole made up of complicated and related parts; "the complex of shopping malls, houses, and roads created a new town" a compound described in terms of the central atom to which other atoms are bound or coordinated (psychoanalysis) a combination of emotions and impulses that have been rejected from awareness but still influence a person's behavior complicated in structure; consisting of interconnected parts; "a complex set of variations based on a simple folk melody"; "a complex mass of diverse laws and customs" building complex: a whole structure (as a building) made up of interconnected or related structures
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| complexion |
the coloring of a person's face a combination that results from coupling or interlinking; "diphthongs are complexions of vowels" a point of view or general attitude or inclination; "he altered the complexion of his times"; "a liberal political complexion" texture and appearance of the skin of the face (obsolete) a combination of elements (of dryness and warmth or of the four humors) that was once believed to determine a person's health and temperament give a certain color to; "The setting sun complexioned the hills"
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| compliance |
conformity: acting according to certain accepted standards; "their financial statements are in conformity with generally accepted accounting practices" happy friendly agreement complaisance: a disposition or tendency to yield to the will of others submission: the act of submitting; usually surrendering power to another
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| complication |
the act or process of complicating a situation or condition that is complex or confused; "her coming was a serious complication" any disease or disorder that occurs during the course of (or because of) another disease; "bed sores are a common complication in cases of paralysis" a development that complicates a situation; "the court's decision had many unforeseen ramifications" complicatedness: puzzling complexity
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| complicated |
difficult to analyze or understand; "a complicated problem"; "complicated Middle East politics"
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| compl | one of a series of enzymes in the blood serum that are part of the immune response |
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| compl | make complete or perfect |
| compl | an immune response in which an antigen-antibody combination inactivates a complement (so it is unavailable to participate in a second antigen-antibody combination) |
| compl | a blood test in which a sample of serum is exposed to a particular antigen and complement in order to determine whether or not antibodies to that particular antigen are present |
| compl | acting as or providing a complement (something that completes the whole) |
| compl | the interrelation of reciprocity whereby one thing supplements or depends on the other |
| compl | a relation between two opposite states or principles that together exhaust the possibilities |
| compl | either one of two chromatic colors that when mixed together give white (in the case of lights) or gray (in the case of pigments) |
| compl | acting as or providing a complement (something that completes the whole) |
| compl | of or relating to or suggestive of complementation |
| compl | of words so related that each is the negation of the other |
| compl | either one of two chromatic colors that when mixed together give white (in the case of lights) or gray (in the case of pigments) |