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hereditary angioneurotic oedema A genetic form of angioedema. (angioedema is also referred to as quinke's disease.) persons with it are born lacking an inhibitor protein (called c1 esterase inhibitor) that normally prevents activation of a cascade of proteins leading to the swelling of angioedema. Patients can develop recurrent attacks of swollen tissues, pain in the abdomen, and swelling of the voice box (larynx) which can compromise breathing. The diagnosis is suspected with a history of recurrent angioedema. It is confirmed by finding abnormally low levels of c1 esterase inhibitor in the blood. Treatment options include antihistamines and male steroids (androgens) that can also prevent the recurrent attacks. Also called hereditary angioedema.
(12 Dec 1998)
hereditary angio oedema <biochemistry> Condition in which there seems to be uncontrolled production of C2 kinin because of a deficiency in C1 inhibitor levels.
(18 Nov 1997)
high altitude cerebral oedema <physiology> A serious condition that results from the sudden increase in pressure within the brain due to swelling. This is thought to occur secondary to exposure to high altitudes, generally in excess of 12,000 feet.
(12 Jan 1998)
high altitude pulmonary oedema <physiology> The abnormal deposition of fluid into the lungs that occurs with exposure to lower barometric pressure and low oxygen.
(12 Jan 1998)
pulmonary oedema <cardiology> A severe state of increased interstitial fluid within the lung that leads to flooding of the alveoli with fluid. This results in a severe disturbance of gas exchange across the alveolar surface. Often results from the ineffective pump function of the heart (noncardiac causes also exist).
(27 Sep 1997)
hydraemic oedema An obsolete term for oedema occurring in states marked by pronounced hydraemia.
(05 Mar 2000)
solid oedema Infiltration of the subcutaneous tissues by mucoid material, as in myxoedema.
(05 Mar 2000)
nephrotic oedema Oedema resulting from renal dysfunction.
(05 Mar 2000)
noninflammatory oedema <clinical sign> Oedema due to mechanical or other causes, not marked by inflammation or congestion.
(05 Mar 2000)
nonpitting oedema Swelling of subcutaneous tissues which cannot be indented by compression easily. Usually due to metabolic abnormality, such as increased glycosaminoglycan content, like that which occurs in Graves' disease (pretibial myxoedema) or in early phase of scleroderma.
Synonym: brawny oedema.
(05 Mar 2000)
nutritional oedema A form of swelling caused by insufficient protein intake resulting in hypoproteinaemia and low plasma oncotic pressure.
(05 Mar 2000)
dependent oedema A clinically detectable increase in extracellular fluid volume localised in a dependent area, as of a limb, characterised by swelling or pitting.
(05 Mar 2000)
Quincke's oedema A vascular reaction involving the deep dermis or subcutaneous or submucal tissues, representing localised oedema caused by dilatation and increased permeability of the capillaries and characterised by development of giant wheals.
(18 Nov 1997)
infantile acute haemorrhagic oedema of the skin A generally benign form of cutaneous vasculitis, characterised by ecchymotic purpura, often in a cockade pattern, and inflammatory oedema in infants.
(05 Mar 2000)
inflammatory oedema A swelling due to effusion of fluid in the soft parts surrounding a focus of inflammation.
(05 Mar 2000)
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