| Eisenmenger's defect | The combination of ventricular septal defect with pulmonary hypertension and consequent right-to-left shunt through the defect, with or without an associated overriding aorta. Synonym: Eisenmenger's defect, Eisenmenger's disease, Eisenmenger's tetralogy. (05 Mar 2000) |
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| endocardial cushion defect | <radiology> Persistence of primitive atrioventricular canal and anomalies of AV valves associated with: Down syndrome: in 25% of Trisomy 21 an ECD is present; in 45% of ECD Trisomy 21 is present, asplenia/polysplenia types: complete (AV canal), partial findings: gooseneck deformity on angiogram, increased pulmonary vascularity, enlarged pulmonary artery, enlarged RV, LV, RA; normal LA (secondary to atrial septal defect) (12 Dec 1998) |
| enzyme defect | A disorder resulting from a deficiency (or functional abnormality) of an enzyme. In 1902 Archibald Garrod first attributed a disease to an enzyme defect: an inborn error of metabolism. Today, newborns are routinely screened for certain enzyme defects such as PKU (phenylketonuria) and galactosaemia, an error in the handling (metabolism) of the sugar galactose. (12 Dec 1998) |
| fibrous cortical defect | A common 1 to 3 cm defect in the cortex of a bone, most commonly the lower femoral shaft of a child, filled with fibrous tissue. Nonosteogenic or nonossifying fibroma by convention refers to lesions greater than 3 cm in diameter. See: nonossifying fibroma. Synonym: nonosteogenic fibroma. (05 Mar 2000) |
| uterine filling defect | <radiology> Technical, bubble, blood clot, mucoid material, congenital fold, pseudoadhesions / ridging -- folds long axis, neoplasm, submucosal leiomyoma, adenoma, endometrial carcinoma, pregnancy-related, pregnancy, molar pregnancy, retained conceptus, polyp, septated uterus, synechiae, IUD, iatrogenic (post-op) (12 Dec 1998) |
| filling defect | Displacement of contrast medium by a space-occupying lesion in a radiographic study of a contrast-filled hollow viscus, such as a polyp on a barium enema; also applied to defects in the otherwise uniform distribution of radionuclide in an organ, such as a metastasis in the liver on a 99mTc-sulfur colloid scan. (05 Mar 2000) |
| filling defect in renal collecting system | <radiology> Common causes: transitional cell carcinoma, blood clot, lucent calculus (urate) less common causes: fungus ball, sloughed papilla, fibroepithelial polyp, invasion by hypernephroma, malakoplakia, vessel impression, metastases (12 Dec 1998) |
| lambdoid suture defect | <radiology> Well-defined lucent lesion, classically unilateral, associated with neurofibromatosis (12 Dec 1998) |
| luteal phase defect | Inadequate function of the corpus luteum that may prevent a fertilized egg from implanting in the uterus or may lead to early pregnancy loss. (09 Oct 1997) |
| acute reflex bone atrophy | Atrophy of bones, commonly of the carpal or tarsal bones, following a slight injury such as a sprain. See: causalgia, reflex sympathetic dystrophy. Synonym: acute reflex bone atrophy, posttraumatic osteoporosis, Sudeck's syndrome. Origin: L. English sweat (05 Mar 2000) |
| air-bone gap | The difference between the threshold for hearing acuity by bone conduction and by air conduction. (05 Mar 2000) |
| Albrecht's bone | A small bone between the basioccipital and basisphenoid. (05 Mar 2000) |
| allogeneic bone marrow transplant | <haematology, procedure> A bone marrow transplant using marrow collected from a matched healthy donor, usually a brother or sister. The risks associated with the transplant increase with age and 50 years of age is generally regarded as the upper limit. (13 Nov 1997) |
| alveolar bone | That portion of bone in either the maxilla or the mandible which surrounds and supports the teeth. (12 Dec 1998) |
| alveolar bone loss | The resorption of bone in the supporting structures of the maxilla or mandible as a result of periodontal disease. (12 Dec 1998) |