| divided dose | A definite fraction of a full dose; given repeatedly at short intervals so that the full dose is taken within a specified period, usually one day. Synonym: fractional dose. (05 Mar 2000) |
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| dose | 1. <pharmacology> A quantity to be administered at one time, such as a specified amount of medication. 2. <radiobiology> A general term denoting the quantity of radiation or energy absorbed. For special purposes it must be appropriately qualified. If unqualified, it refers to absorbed dose. Unit of absorbed dose is the rad. The SI unit is the gray (1 Gy = 1 J kg-1 = 100 R). Origin: Gr. Dosis = a giving (16 Dec 1997) |
| dose-effect curve | This is a graph drawn to show the relationship between the dose of a drug or other chemical and the magnitude of the graded effect that it produces. (09 Oct 1997) |
| dose-escalation | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |
| dose fractionation | Adminstration of the total dose of radiation (radiation dosage) in parts, at timed intervals. (12 Dec 1998) |
| dose intensity | In chemotherapy, the total amount of drug delivered in a one-week period. Can be given all at once or over a period of several days. (16 Dec 1997) |
| dose-ranging | A preliminary clinical trial in which the amount of the drug is either periodically increased or increased with each new trial arm that is added. Used to determine how a drug is tolerated in people. (09 Oct 1997) |
| dose-response curve | This is a graph to show the relation between the dose of a drug or other chemical and the degree of response it produces, as measured by the percentage of the exposed population showing a defined, often quantal, effect. (09 Oct 1997) |
| dose-response relationship | Relationship in which a change in the amount, intensity, or duration of exposure is associated with a change in risk of a specified outcome. (05 Mar 2000) |
| dose-response relationship, drug | The relationship between the dose of an administered drug and the response of the organism to the drug. (12 Dec 1998) |
| dose-response relationship, immunologic | A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell. (12 Dec 1998) |
| dose-response relationship, radiation | The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. (12 Dec 1998) |
| immunologic high dose tolerance | Induction of tolerance by exposure to large amounts of protein antigens. (05 Mar 2000) |
| initial dose | A comparatively large dose given at the beginning of treatment to get the patient under the influence of the drug. Synonym: loading dose. (05 Mar 2000) |
| integral dose | The total energy absorbed by the body, the product of the mass of tissue irradiated and the absorbed dose; unit, the gram rad. (05 Mar 2000) |