| CMMoL | chronic myelomonocytic leukemia |
|---|---|
| MLC | minimum lethal concentration; mixed leukocyte culture; mixed ligand chelate; mixed lymphocyte concen... |
| MLS | mean lifespan; median life span; median longitudinal section; microphthalmia-linear skin defects [sy... |
| MML | Moloney murine leukemia; monomethyllysine; myelomonocytic leukemia |
| CD | Cluster of differentiation |
| antigens, CD14 | <immunology> Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (lps) and lps-binding protein. (12 Dec 1998) |
|---|---|
| antigens, CD15 | <immunology> Carbohydrate antigen which is accumulated in various human cancer tissues and secreted into the blood stream. The carbohydrate moiety can be further modified with fucose or sialic acid. Monoclonal antibodies have been determined which can discriminate each subgroup of this antigen in the sera of cancer patients. Sialyl ssea-1 antigen is particularly elevated in the sera of patients with a variety of tumours. (12 Dec 1998) |
| antigens, CD18 | <immunology> Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (receptors, leukocyte-adhesion). A defect in the gene encoding CD18 causes leukocyte-adhesion deficiency syndrome. (12 Dec 1998) |
| antigens, CD19 | <immunology> Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation. (12 Dec 1998) |
| antigens, CD2 | <immunology> Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex. (12 Dec 1998) |
| antigens, CD20 | <immunology> Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane calcium conductance and thought to play a role in B-cell activation and proliferation. (12 Dec 1998) |
| antigens, CD26 | <enzyme, immunology> Cell-surface glycoproteins and serine protease, also known as dipeptidyl-peptidase IV, that play a role in t-lymphocyte activation. Cd26 binds to adenosine deaminase on the T-cell surface. Registry number: EC 3.4.14.5 (12 Dec 1998) |
| antigens, CD27 | <immunology> Dimeric membrane glycoproteins found on most T-lymphocytes. Activation of T-cells by the antigen receptor increases CD27 surface expression. (12 Dec 1998) |
| antigens, CD28 | <immunology> T-cell differentiation antigens that serve as the receptors for the b7 antigen (antigens, CD80) which modulates T-cell lymphokine production. (12 Dec 1998) |
| antigens, CD29 | <immunology> Integrin beta-1 chains which are expresssed as heterodimers noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). Cd29 is expressed on resting and activated leukocytes and is a marker for total very late activation antigens on cells. (barclay et al., the leukocyte antigen factsbook, 1993, p164) (12 Dec 1998) |
| antigens, CD3 | <immunology> A complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (receptors, antigen, T-cell). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (receptors, antigen, T-cell, gamma-delta). (12 Dec 1998) |
| antigens, CD30 | <immunology> Differentiation antigens normally present in a small number of cells in the lymph nodes and tonsils in vivo, but also capable of being induced in a wide range of cells in vitro. They are clinically useful as tumour markers for ki-1 lymphoma (lymphoma, large-cell, ki-1) and some cases of lymphomatoid papulosis, mycosis fungoides, and hodgkin's disease. (12 Dec 1998) |
| antigens, CD31 | <immunology> Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. Cd31 is highly expressed on endothelial cells and concentrated at the junctions between them. (12 Dec 1998) |
| antigens, CD34 | <immunology> Glycoproteins found on immature haematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow. (12 Dec 1998) |
| antigens, CD36 | <immunology> Leukocyte differentiation antigens and major platelet membrane glycoproteins present on monocytes, endothelial cells, platelets, mammary epithelial cells, and a variety of cultured cell lines. They play major roles in adhesion phenomena, signal transduction, and haematopathology. Cd36 is also the receptor for thrombospondin and malaria-infected erythrocytes. (12 Dec 1998) |