| antigens, CD8 | <immunology> Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. Cd8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in major histocompatibility complex class I-restricted interactions. (12 Dec 1998) |
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| antigens, CD80 | <immunology> The natural ligand for the T-cell antigen CD28 (antigens, CD28) mediating t-cell and B-cell adhesion. Cd80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes. The binding of CD80 to CD28 and ctla-4 provides a co-stimulatory signal to T-cells and leads to greatly upregulated lymphokine production. (12 Dec 1998) |
| antigens, CD95 | <immunology> Differentiation antigens expressed on a variety of cell lines including myeloid and lymphoblastoid cell lines. Their primary role is to regulate peripheral immune responses, which is achieved by triggering apoptosis. (12 Dec 1998) |
| class III antigens | Non-cell membrane molecules that are encoded by the S region of the major histocompatibility complex. These antigens are not involved in determining histocompatibility and include the complement proteins. (05 Mar 2000) |
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| minor histocompatibility antigens | Allelic alloantigens often responsible for weak graft rejection in cases when (major) histocompatibility has been established by standard tests. In the mouse they are coded by more than 500 genes at up to 30 minor histocompatibility loci. The most well-known minor histocompatibility antigen in mammals is the h-y antigen. (12 Dec 1998) |
| minor lymphocyte stimulatory antigens | Endogenous superantigens responsible for inducing strong proliferative responses in T-cells in mixed lymphocyte reactions (see mixed lymphocyte culture test). They are encoded by mouse mammary tumour viruses that have integrated into the germ line as DNA proviruses (minor lymphocyte stimulatory loci). (12 Dec 1998) |
| MN blood group antigens | <haematology, immunology> A pair of blood group antigens governed by genes that segregate independently of the ABO locus. The alleles are codominant and there are three types MM, NN and MN. Glycophorin has M or N activity and this is associated with oligosaccharides attached to the amino terminal portion of the molecule. M type glycophorin differs from N type in amino acid residues 1 and 5, although the antigenic determinants are associated with the carbohydrate side chains. (18 Nov 1997) |
| hepatitis antigens | Antigens from any of the hepatitis viruses including surface, core, and other associated antigens. (12 Dec 1998) |
| hepatitis b e antigens | A closely related group of antigens found in the plasma only during the infective phase of hepatitis b or in virulent chronic hepatitis b, probably indicating active virus replication; there are three subtypes which may exist in a complex with immunoglobulins g. (12 Dec 1998) |
| hepatitis b surface antigens | Those hepatitis b antigens found on the surface of the dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen. (12 Dec 1998) |
| hepatitis c antigens | Antigens of the virions of hepatitis c-like viruses, their surface, core, or other associated antigens. (12 Dec 1998) |
| histocompatibility antigens | A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection. (12 Dec 1998) |
| histocompatibility antigens class I | Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-a, HLA-b and HLA-c antigens. In mice, three genes named k, d, and l on chromosome 17 code for the h-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognised during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders. (12 Dec 1998) |
| histocompatibility antigens class II | Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-d antigens and are coded by a gene on chromosome 6. In mice, two genes named ia and i.e. On chromosome 17 code for the h-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term ia antigens used to refer only to the proteins encoded by the ia genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen. (12 Dec 1998) |
| HIV antigens | Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (lav) antigens. (12 Dec 1998) |
| HLA-a antigens | <immunology> Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. at least 20 antigens have been identified which are encoded by the a locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts. (12 Dec 1998) |
| HLA antigens | <immunology> A complex family of genetically inherited proteins which are found on the surface of cells throughout the body. They determine the match between patient and potential donor in bone marrow transplantation. These factors are inherited from the mother and father and so the chance of having the same HLA antigens between siblings is 1 in 4. See: human lymphocyte antigens. (20 Jun 2000) |
| HLA-b antigens | <immunology> Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus b of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-b27, -b7, -b8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic t lymphocytes. (12 Dec 1998) |
Synonyms : Basigin, Basigin Protein, CD147 Antigen, Emmprin, Emmprin Protein, Extracellular Matrix Metalloproteinase Inducer (EMMPRIN), Antigen, CD147
Synonyms : 3-Fucosyl-N-acetyl-lactosamine, 3-Fucosyllactosamine Determinant, CD15 Antigen, Hapten X, Hapten Y, Lewis X Hapten, SSEA 1, SSEA 1 Determinant, 1 Determinant, SSEA, 3 Fucosyl N acetyl lactosamine, 3 Fucosyllactosamine Determinant, Determinant, SSEA 1
Synonyms : CD164 Antigen, Endolyn, Antigen, CD164
Synonyms : CD18 Antigen, beta2 Integrin, p150, 95 beta-Subunit, Integrin, beta2, beta-Subunit, p150, 95, beta2, Integrin, p150, 95 beta Subunit
Synonyms : B Cell Antigen CD19, CD19 Antigen, Antigen, CD19