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antigenic m. alteration or loss of reactivity of cell surface antigens resulting from redistribution of antigenic sites due to the presence of bound antibody.
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antigenic p. the total antigenic content and structure of a tissue or cell.
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antigenic r. a change in the antigenic structure of adult cells to that of immature cells, as in certain tumors.
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antigenic s. a sudden, major change in the antigenicity of a virus, seen especially in influenza viruses, resulting from the recombination of the genomes of two virus strains; it is associated with pandemics because hosts do not have immunity to the new strain. Cf. antigenic drift, under drift.
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antigenic v. 1. a mechanism whereby parasites, such as trypanosomes, plasmodia, and Borrelia, are enabled to escape immune surveillance of a host by modifying or completely altering their surface antigens.  2. a phenomenon occurring in the influenza virus, in which the virus spontaneously exhibits both slow antigenic drift and sharp antigenic changes at intervals.
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