| ACT | achievement through counseling and treatment; actin; actinomycin; activated clotting time; advanced ... |
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| A-LAK | adherent lymphokine-activated killer [cell] |
| APC | acetylsalicylic acid, phenacetin, and caffeine; activated protein C; adenoidal-pharyngeal-conjunctiv... |
| APTT, aPTT | activated partial thromboplastin time |
| ATC | activated thymus cell; around the clock |
| TNF-IL1-activated protein kinase | <enzyme> Phosphorylates beta casein in vitro; not the same as casein kinase 1 and casein kinase 2; not activated by mitogens, celllular stresses or any other cytokines than il1 and tnf Registry number: EC 2.7.1.- Synonym: tip kinase, beta casein kinase (26 Jun 1999) |
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| Fas-activated serine-threonine kinase | <enzyme> Phosphorylates tia-1 during fas-mediated apoptosis; contains proline-rich sh3-binding domains; mw 60-63 kD; genbank x86779 Registry number: EC 2.7.10.- Synonym: fast kinase (26 Jun 1999) |
| killer cells, lymphokine-activated | Cytolytic lymphocytes with the unique capacity of killing natural killer (nk)-resistant fresh tumour cells. They are interleukin-2-activated nk cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. Lak cells are used for adoptive immunotherapy in cancer patients. (12 Dec 1998) |
| fluorescence-activated cell sorter | <technique> Flow cytometry is an emerging technique which holds great promise for the separation, classification and quantitation of blood cells and antibodies which affect blood cells. Complex computerised instruments are used to pass a monocellular stream of cells, platelets or other microscopic particulate elements through a beam of laser light. The cells are categorised first by size and then computer analysed to sort the mixture of cellular elements into cell type by size. Cells are labelled with fluorescent dye and then passed, in suspending medium, through a narrow dropping nozzle so that each cell is in a small droplet. A laser based detector system is used to excite fluorescence and droplets with positively fluorescent cells are given an electric charge. Charged and uncharged droplets are separated as they fall between charged plates and so collect in different tubes. The machine can be used either as an analytical tool, counting the number of labelled cells in a population or to separate the cells for subsequent growth of the selected population. Further sophistication can be built into the system by using a second laser system at right angles to the first to look at a second fluorescent label or to gauge cell size on the basis of light scatter. The great strength of the system is that it looks at large numbers of individual cells and makes possible the separation of populations with, for example: particular surface properties. Tabulation of counted data in conjunction with size analysis enables determination of relative percentages of each specific cellular subset for which monoclonal antibody conjugates are utilised, even when the size of the cell is identical to other subset species. Flow cytometry is a slightly imprecise but common term for the use of the Fluorescence-activated Cell Sorter (FACS). (01 Dec 1998) |
| fluorescence-activated cell sorting | <technique> A technique for separating and sorting cells marked with a fluorescent label based on how much they fluoresce at a particular wavelength. (12 Jan 1998) |
| light-activated resin | A resin which uses visible or ultraviolet light to excite a photoinitiator which interacts with an amine to form free radicals and initiate polymerization. Used mainly in restorative dentistry. Synonym: light-activated resin. (05 Mar 2000) |
| Abbott's method | A method of treatment of scoliosis by use of a series of plaster jackets applied after partial correction of the curvature by external force. (05 Mar 2000) |
| Abell-Kendall method | A standard method for estimation of total serum cholesterol involving saponification of cholesterol ester by hydroxide, extraction with petroleum ether, and colour development with acetic anhydride-sulfuric acid; the method avoids interference by bilirubin, protein, and haemoglobin. (05 Mar 2000) |
| Altmann-Gersh method | The method of rapidly freezing a tissue and dehydrating it in a vacuum. (05 Mar 2000) |
| Anel's method | Ligation of an artery immediately above (on the proximal side of) an aneurysm. (05 Mar 2000) |
| Antyllus' method | Ligation of the artery above and below an aneurysm, followed by incision into and emptying of the sac. (05 Mar 2000) |
| aristotelian method | A method of study that stresses the relation between a general category and a particular object. (05 Mar 2000) |
| Ashby method | A differential agglutination method for estimating erythrocyte life span; compatible blood possessing a group factor that the recipient lacks is transferred to the recipient; after the transfusion, sera with potent agglutinins for the recipient's red cells are added to samples of the recipient's blood, and the unagglutinated red cells are counted; using this technique the red cell life span in normal persons is found to be 110 to 120 days. (05 Mar 2000) |
| auxanographic method | A method for the study of bacterial enzymes in which agar is mixed with the material (e.g., starch or milk) which is to serve as an indicator of the enzyme action and is inoculated and plated; if the bacteria produce enzymes digesting the admixed material, there will be a zone of clearing in the medium about each colony. Synonym: diffusion method. (05 Mar 2000) |
| Barraquer's method | Zonulysis Dissolution of the zonula ciliaris by enzymes (alpha-chymotrypsin) to facilitate surgical removal of a cataract. Synonym: Barraquer's method. Origin: zonule + G. Lysis, dissolution (05 Mar 2000) |